Immunoglobulin E-Mediated Allergy Plays a Role in Atopic Eczema as Shown in the Atopy Patch Test

World Allergy Organization Journal

Johannes Ring¹  Ulf Darsow¹ 

[1] Department of Dermatology and Allergy Biederstein, Division of Environmental Dermatology and Allergy GSF/TUM, Technical University Munich, Biedersteiner Straße 29, D-80802 München, Germany

关键词: atopic eczema;    atopy patch test;    diagnostic techniques;    IgE;   

Others  :  825191
DOI  :  10.1097/WOX.0b013e3181661472

 received in 2007-12-20, accepted in 2007-12-20,  发布年份 2008

【 摘 要 】

Although the pathophysiology of immunoglobulin E (IgE)-mediated allergic rhinoconjunctivitis and bronchial asthma is rather well established, the role of allergy in atopic eczema (AE) is still controversial. By a technique called atopy patch test, aeroallergens like house dust mite, animal dander, or pollen were proven as relevant trigger factors in a subgroup of patients with AE. The atopy patch test is an epicutaneous patch test with such allergens known to elicit IgE-mediated reactions, and used for the evaluation of eczematous skin reactions. In a series of single-center and multicenter studies, a method was developed, standardized, and compared with other diagnostic techniques (radioallergosorbent test, skin prick test) in AE patients. With regard to clinical history, the most specific results were obtained with the atopy patch test (allergen-dependent, 69%-92%), whereas sensitivity was higher for skin prick test (range, 69%-82%) and specific IgE (range, 65%-94%). The characterization of a patient subgroup with relevant IgE-mediated allergy may lead to more efficient avoidance and eventually even specific immunotherapy strategies in the management of AE.

【 授权许可】

   
2008 World Allergy Organization; licensee BioMed Central Ltd.

【 图 表 】

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