Research advances on flotillins

Virology Journal

Ya-Li He¹  Li Li²  Yong-Sheng Liu³  Jie Zhang³  Feng Zhao³ 

[1] School of Public Health, Lanzhou university, Lanzhou, 730000, Gansu, P.R. China;The People's Government of Huaikou Town in Jintang County of Chengdu City , Chengdu, 610404, Sichuan, P.R. China;State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences. Lanzhou, 730046, Gansu, P.R. China

关键词: GPI-anchored proteins;    Prion protein;    Signal transduction;    Lipid raft;    Flotillin-2;    Flotillin-1;   

Others  :  1155831
DOI  :  10.1186/1743-422X-8-479

 received in 2011-08-17, accepted in 2011-10-25,  发布年份 2011

【 摘 要 】

The proteins of flotillin-1 and flotillin-2 were originally discovered in axon regeneration of goldfish retinal ganglion cells. They are generally used as marker proteins of lipid rafts and considered to be scaffolding proteins of lipid microdomains. Although they are ubiquitously expressed and well-conserved from fly to man, their exact functions remain controversial. In this review, we summarize the structure of flotillins and some functions of them, such as regulating axon regeneration, endocytosis, T cell activation, insulin signaling, membrane protein recruitment, roles in the progression of some diseases and so on.

【 授权许可】

   
2011 Zhao et al; licensee BioMed Central Ltd.

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