Prevalence and risk factors of vitamin D deficiency in inherited ichthyosis: A French prospective observational study performed in a reference center

Orphanet Journal of Rare Diseases

Juliette Mazereeuw-Hautier⁴  Jean-Pierre Salles³  Khaled Ezzedine¹  Isabelle Gennero²  Lauriane Rodriguez⁴  Isabelle Dreyfus⁴  Flora Frascari⁴ 

[1] Department of Dermatology and Pediatric Dermatology, National Center for Rare Skin Disorders, Saint André Hospital, Bordeaux University Hospital, Bordeaux, France;Biochemistry Laboratory, Federative Institute of Biology, Toulouse University Hospital, Toulouse, France;Unit of Endocrinology, Genetics, Gynecology and Bone Diseases, Children’s Hospital, Toulouse, National Center for Rare Diseases of Calcium and Phosphorus metabolism, Toulouse, France;Paul Sabatier University and Department of Dermatology, Rare Skin Diseases Reference Center, Larrey Hospital, CHU Toulouse, Toulouse, France

关键词: Risk factors;    Prevalence;    Vitamin D deficiency;    Genodermatosis;    Inherited ichthyosis;   

Others  :  1150007
DOI  :  10.1186/s13023-014-0127-3

 received in 2014-03-12, accepted in 2014-07-25,  发布年份 2014

【 摘 要 】

Background

To date, few studies have investigated serum vitamin D status in patients with inherited ichthyosis. The aim of this study was to determine the prevalence of vitamin D deficiency (defined as serum level <10 ng/mL) in a French cohort of patients and to identify associated risk factors.

Methods

This was a prospective observational study performed in a hospital reference center with expertise for rare skin diseases. Patients’ clinical characteristics were recorded. Serum concentration of 25-hydroxyvitamin D and parathyroid hormone were determined. For patients with vitamin D deficiency, serum calcium, serum phosphorus and bone mineral density were also investigated. Comparisons between groups (25-hydroxyvitamin D <10 ng/mL versus ≥10 ng/mL) were conducted by univariate and multivariate logistic regression.

Results

Of the 53 included patients, 47 (88.7%) had serum 25-hydroxyvitamin D below the optimal level of 30 ng/mL: 18 (34%) had vitamin D sufficiency, 14 (26.4%) had vitamin D insufficiency, and 15 (28.3%) had vitamin D deficiency. A negative linear correlation was found between 25-hydroxyvitamin D and parathyroid hormone levels for the whole study population. Serum calcium and phosphorus levels were normal for the 15 patients with vitamin D deficiency. Bone mineral density was investigated for 11 of these latter 15 patients, and six of them had osteopenia. Winter/spring seasons of vitamin D measurement, severity of ichthyosis, and phototypes IV–VI were identified as independent risk factors for vitamin D deficiency.

Conclusions

Clinicians should be aware of the risk of vitamin D deficiency in the management of patients with inherited ichthyosis, especially in winter and spring, and in case of dark skin or severe disease.

【 授权许可】

   
2014 Frascari et al. ; Licensee Biomedcentral

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