Comparing treatment outcomes of different chemotherapy sequences during intensity modulated radiotherapy for advanced N-stage nasopharyngeal carcinoma patients

Radiation Oncology

Taixiang Lu¹  Shuai Liu¹  Weiwei Xiao¹  Fei Han¹  Ying Huang¹  Chunyan Chen¹  Lei Zeng¹  Xueming Sun¹ 

[1] Department of Radiation Oncology, Cancer Center of Sun Yat-Sen University, NO.651 Dongfeng east road, Guangzhou City 510060, Guangdong Province, PR China

关键词: Prognosis;    Chemotherapy;    Intensity-modulated radiotherapy;    Advanced N-stage;    Nasopharyngeal carcinoma;   

Others  :  1152413
DOI  :  10.1186/1748-717X-8-265

 received in 2013-04-20, accepted in 2013-10-20,  发布年份 2013

【 摘 要 】

Background

N-stage is related to distant metastasis of nasopharyngeal carcinoma (NPC) patients. We performed this study to compare the efficacy of different chemotherapy sequences in advanced N-stage (N2 and N3) NPC patients treated with intensity modulated radiotherapy (IMRT).

Methods

From 2001 to 2008, 198 advanced N-stage NPC patients were retrospectively analyzed. Thirty-three patients received IMRT alone. Concurrent chemoradiotherapy (CCRT) was delivered to 72 patients, neoadjuvant chemotherapy (NACT) + CCRT to 82 patients and CCRT + adjuvant chemotherapy (AC) to 11 patients.

Results

The 5-year overall survival rate, recurrence-free survival rate, distant metastasis-free survival rate and progress-free survival rate were 47.7% and 73.1%(p<0.001), 74.5% and 91.3% (p = 0.004), 49.2% and 68.5% (p = 0.018), 37.5% and 63.8% (p<0.001) in IMRT alone and chemoradiotherapy group. Subgroup analyses indicated that there were no significant differences among the survival curves of CCRT, NACT + CCRT and CCRT + AC groups. The survival benefit mainly came from CCRT. However, there was only an improvement attendency in distant metastasis-free survival rate of CCRT group (p = 0.107) when compared with RT alone group, and NACT + CCRT could significantly improve distant metastasis-free survival (p = 0.017).

Conclusions

For advanced N-stage NPC patients, NACT + CCRT might be a reasonable treatment strategy.

【 授权许可】

   
2013 Sun et al.; licensee BioMed Central Ltd.

【 图 表 】

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