Soft tissue perineurioma of the tongue: report of a case and review of the literature

World Journal of Surgical Oncology

Yao-xiang Xu¹  Ling-fa Xue²  Wen-lin Xiao¹ 

[1] Department of Oral and Maxillofacial Surgery, The Medical School Hospital of Qingdao University, No. 1677, Wutaishan Road, Qingdao 266555, People’s Republic of China;Department of Pathology, The Medical School Hospital of Qingdao University, No. 1677, Wutaishan Road, Qingdao, People’s Republic of China

关键词: Tongue;    Soft tissue;    Perineurioma;   

Others  :  820569
DOI  :  10.1186/1477-7819-12-11

 received in 2013-07-20, accepted in 2013-12-23,  发布年份 2014

【 摘 要 】

Perineurioma is a rare benign tumor of the peripheral nervous system distinct from schwannomas and neurofibromas. It may be intraneural or extraneural (in the soft tissue). Extraneural soft tissue perineuriomas are uncommon; rare cases have been reported in the oral cavity. We present a case of soft tissue perineurioma in the tip of the tongue. The tumor was characterized by slender spindle cells, arranged in short fascicles or whorls, and focal areas showing a distinct storiform pattern. Tumor cells showed the immunohistochemical profile of perineurial cells, including epithelial membrane antigen. Smooth muscle actin, S-100, and CD34 were not expressed by the tumor cells. The tumor was surgically excised and in 2 years there has been no recurrence. Knowledge of the tumor in the oral cavity is important to reach a correct diagnosis and to avoid unnecessary aggressive local excision.

【 授权许可】

   
2014 Xiao et al.; licensee BioMed Central Ltd.

【 图 表 】

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【 参考文献 】

• [1]Hornick JL, Fletcher CD: Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features. Am J Surg Pathol 2005, 29:845-858.
• [2]Emory TS, Scheithauer BW, Hirose T, Wood M, Onofrio BM, Jenkins RB: Intraneural perineurioma. A clonal neoplasm associated with abnormalities of chromosome 22. Am J Clin Pathol 1995, 103:696-704.
• [3]Tsang WY, Chan JK, Chow LT, Tse CC: Perineurioma: an uncommon soft tissue neoplasm distinct from localized hypertrophic neuropathy and neurofibroma. Am J Surg Pathol 1992, 16:756-763.
• [4]Macarenco RS, Ellinger F, Oliveira AM: Perineurioma: a distinctive and underrecognized peripheral nerve sheath neoplasm. Arch Pathol Lab Med 2007, 131:625-636.
• [5]Damm DD, White DK, Merrell JD: Intraneural perineurioma - not restricted to major nerves. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003, 96:192-196.
• [6]Adachi S, Doi R, Mitani K, Iwamoto Y, Furumoto A, Yamashita M, Cho H: Atypical soft tissue perineurioma in the tongue of a young girl. Pathol Int 2010, 60:787-791.
• [7]da Cruz Perez DE, de Aguiar FC A Jr, Leon JE, Graner E, Paes de Almeida O, Vargas PA: Intraneural perineurioma of the tongue: a case report. J Oral Maxillofac Surg 2006, 64:1140-1142.
• [8]Mentzel T, Dei Tos AP, Fletcher CD: Perineurioma (storiform perineurial fibroma): clinico-pathological analysis of four cases. Histopathology 1994, 25:261-267.
• [9]Balarezo FS, Muller RC, Weiss RG, Brown T, Knibbs D, Joshi VV: Soft tissue perineuriomas in children: report of three cases and review of the literature. Pediatr Dev Pathol 2003, 6:137-141.
• [10]Gruen JP, Mitchell W, Kline D: Resection and graft repair for localized hypertrophic neuropathy. Neurosurgery 1998, 43:78-83.
• [11]Kim HJ, Yang I, Jung AY, Woo JY, Hong HS, Jeh SK, Kim HK, Kim JW: Ultrasound and MR findings in sclerosing perineurioma. Skeletal Radiol 2011, 40:353-355.
• [12]Pinkus GS, Kurtin PJ: Epithelial membrane antigen - a diagnostic discriminant in surgical pathology: immunohistochemical profile in epithelial, mesenchymal, and hematopoietic neoplasms using paraffin sections and monoclonal antibodies. Hum Pathol 1985, 16:929-940.
• [13]Gengler C, Guillou L: Solitary fibrous tumour and haemangiopericytoma: evolution of a concept. Histopathology 2006, 48:63-74.
• [14]Smith ME, Awasthi R, O’Shaughnessy S, Fisher C: Evaluation of perineurial differentiation in epithelioid sarcoma. Histopathology 2005, 47:575-581.
• [15]Bégin LR: Perineurioma of the finger: case report of a rare peripheral nerve sheath neoplasm of pure perineurial cell lineage. J Hand Surg 1998, 23:342-347.
• [16]Giannini C, Scheithauer BW, Jenkins RB, Erlandson RA, Perry A, Borell TJ, Hoda RS, Woodruff JM: Soft-tissue perineurioma. Evidence for an abnormality of chromosome 22, criteria for diagnosis, and review of the literature. Am J Surg Pathol 1997, 21:164-173.
• [17]Fang WS, Emerson LL, Hunt JP, Salzman KL: An unusual sinonasal tumor: soft tissue perineurioma. AJNR Am J Neuroradiol 2009, 30:437-439.
• [18]Meer S, Coleman H, Altini M: Intraoral perineurioma: report of a case with a review of the literature. Oral Dis 2003, 9:99-103.