Radiation Oncology | |
AP-PA field orientation followed by IMRT reduces lung exposure in comparison to conventional 3D conformal and sole IMRT in centrally located lung tumors | |
Natan Shtraus1  Haim Tempelhoff1  Eliahu Gez1  Dan Schifter1  Benjamin W Corn1  Yaron Meir1  Viacheslav Soyfer1  | |
[1] Tel Aviv Sourasky Medical Center, Radiation Oncology Department, 6 Weizman Street, Tel Aviv 64239, Israel | |
关键词: AP-PA; 3D; IMRT; Radiation; Lung cancer; | |
Others : 1160893 DOI : 10.1186/1748-717X-7-23 |
|
received in 2011-09-22, accepted in 2012-02-16, 发布年份 2012 | |
【 摘 要 】
Little attention has been paid to the fact that intensity modulated radiation therapy (IMRT) techniques do not easily enable treatment with opposed beams. Three treatment plans (3 D conformal, IMRT, and combined (anterior-posterior-posterio-anterior (AP-PA) + IMRT) of 7 patients with centrally-located lung cancer were compared for exposure of lung, spinal cord and esophagus. Combined IMRT and AP-PA techniques offer better lung tissue sparing compared to plans predicated solely on IMRT for centrally-located lung tumors.
【 授权许可】
2012 Soyfer et al; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
20150411083408426.pdf | 918KB | download | |
Figure 4. | 41KB | Image | download |
Figure 3. | 60KB | Image | download |
Figure 2. | 23KB | Image | download |
Figure 1. | 27KB | Image | download |
【 图 表 】
Figure 1.
Figure 2.
Figure 3.
Figure 4.
【 参考文献 】
- [1][http://seer.cancer.gov/csr/1975_merged/sect_15lung_bronchus.pdf11] webcite
- [2]Bradley J, Graham MV, Winter K, Purdy JA, Komaki R, Roa WH, Ryu JK, Emami B: Toxicity and outcome results of RTOG 9311: a phase 1-2 dose escalation study using three- dimensional conformal radiotherapy (> 59 Gy) and concurrent chemotherapy in non-small-cell lung cancer. Ann Thorac Surg 2004, 78:1200-5.
- [3]Kong F, Gaspar LE, Komaki R, Sun A, Bonner JA, Choy H, Wang L, Morris D, Sandler HM, Movsas B: Patterns of practice in radiation dose prescription and treatment planning for patients with lung cancer among members of American Society of Therapeutic Radiology and Oncology (abstract). Int J Radiat Oncol Biol Phys 2007, 69(3 Suppl 1):483.
- [4]Wang L, Correa CR, Zhao L, Hayman J, Kalemkerian GP, Lyoms S, Cease K, Brenner D, Kong FM: The effect of radiation dose and chemotherapy on overall survival in 237 patients with Stage 3 non-small cell lung cancer. Int J Radiat Oncol Biol Phys 2007, 68:103-10.
- [5]Payne D, Warde P: Does thoracic irradiation improve survival and local control in limited-stage small-cell carcinoma of the lung? A meta-analysis. J Clin Oncol 1992, 10(6):890-5.
- [6]Zhu H, Zhou ZM, Ou GF, Liang J, Zhang XR, Zhang HX, Chen DF, Xiao ZFWang LH: Thoracic Radiation Therapy (TRT) Improved Overall Survival for Patients with Extensive Stage Small Cell Lung Cancer. Int J Radiat Biol Phys 2010, 78(3):522-523.
- [7][http://www.nccn.org/professionals/physician_gls/pdf/sclc.pdf] webcite
- [8]Graham MV, Pudry JA, Emami B, Harms W, Bosch W, Lockett MA, Perez CA: Clinical dose-volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC). Int J Radiat Ocnol Biol Phys 1999, 45(2):323-9.
- [9]Singh A, Locket MA, Bradly JD: Predictors of radiation-induced esophageal toxicity in patients with non-small-cell lung cancer treated with three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys 2003, 55(2):337-41.
- [10]Lievens Y, Nulens A, Gaber MA, Defraene G, Wever WD, Stroobants S, Heuvel FD: Intensity Modualated Radiotherapy for locally advanced Non-Small-Cell Lang Cancer: A dose-escalation planning study. Int J Radiat Oncol Biol Phys 2011, 80(1):306-13.
- [11]Kitpatrick JP, Van Der Kogel AJ, Schultheiss TE: Radiation dose-volume effects in spinal cord. Int J Radiat Oncol Biol Phys 2010, 76(3 Suppl):S42-9.
- [12]Liu H, Wang X, Dong L, Wu Q, Stevens CW, Guerrero TM, Komaki R, Cox JD, Mohan R: Feasibility of sparing lung and other thoracic structures with intensity-modulated radiotherapy for non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 2004, 58:1268-1279.
- [13]Murshed S, Liu H, Liao Z, Barker JL, Wang X, Tucker SL, Chandra A, Stevens C, Chang JY, Jeter M, Cox JD, Komaki R, Mohan R: Dose and volume reduction for normal lung using intensity-modulating radiotherapy for advanced stage non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 2004, 58(4):1258-1267.
- [14]Allen AM, Czerminska M, Janne PA, et al.: Fatal pneumonitis associated with intensity-modulated radiation therapy for mesothelioma. Int J Radiat Oncol Biol Phys 2006, 65:640-645.
- [15]Mayo CS, Urie MM, Fitzgerald TJ, Ding L, Lo YC, Bogdanov M: Hybrid IMRT for treatment of cancer of the lung and esophagus. Int J Radiat Oncol Biol Phys 2008, 71(5):1408-1418.
- [16]Chan OS, Lee MC, Hung AW, Chang AT, Yeung RM, Lee AW: The superiority of hybrid- volumetric arc therapy (VMAT) technique over double arc VMAT and 3D- conformal technique in the treatment of locally advanced non-small cell lung cancer- A planning study. Radiother Oncol 2011, 101(2):298-302. Epub 2011 Sep 8
- [17]Jatinder R, Palta T: Rockwell Mackie: Intensity- Modulated radiation Therapy. The State of the Art 2003, 67.
- [18]International Commission on Radiation Units and Measurements: Prescribing, recording and reporting photon beam therapy ICRU Report 62. Bethesda, MD: international Commission on Radiation Units and Measurements; 2010.
- [19]Onimaru R, Shirato H, Fujino M, et al.: The effect of tumor location and respiratory function on tumor movement estimated by real-time tracking radiotherapy (RTRT) system. Int J Radiat Oncol Biol Phys 2005, 63(1):164-169.
- [20]Plathow C, Fink C, Ley S, et al.: Measurement of tumor diameter-dependent mobility of lung tumors by dynamic MRI. Radiother Oncol 2004, 73(3):349-354.
- [21]Perez C, Brady WL, Halperin CE, Schmidt-Ullrich RK: Principles and Practice of Radiation Oncology. fourth edition. 2004, 1218.
- [22]Halperin CE, Perez C, Brady : Principles and Practice of Radiation Oncology. fifth edition. 2008, 1103.
- [23]Claude L, Perol D, Ginestet C, et al.: A prospective study on radiation pneumonitis following conformal radiation therapy in non-small-cell lung cancer: Clinical and dosimetric factors analysis. Radiother Oncol 2004, 71:175-181.
- [24]Shueng PW, Lin SC, Chang HT, Chong NS, Chen YJ, Wang LY, Hsieh YP, Hsieh CH: Toxicity risk on non-target organs at risk receiving low-dose radiation: case report. Radiat Oncol 2009, 4:71. BioMed Central Full Text
- [25]Shi A, Zhu G, Wu H, Yu R, Li F, Xu B: Analysis of clinical and dosimetric factors associated with severe acute radiation pneumonitis in patients with locally advanced non-smal cell lung cancer treated with concurrent chemotherapy and intensity- modulated radiotherapy. Radiat Oncol 2010, 5:35. BioMed Central Full Text