Accuracy of deformable image registration for contour propagation in adaptive lung radiotherapy

Radiation Oncology

Wolfgang A Tomé³  Karl Bzdusek⁴  Dirk De Ruysscher²  Wouter van Elmpt¹  Nicholas Hardcastle⁵ 

[1] Department of Radiation Oncology (MAASTRO), GROW – School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, Netherlands;Radiation Oncology, University Hospitals Leuven/ KU Leuven, Leuven, Belgium;Department of Radiation Oncology, Montefiore Medical Center and Institute for Onco-Physics, Albert Einstein College of Medicine, Bronx, NY 10461, USA;Philips Radiation Oncology Systems, 5520 Nobel Drive, 53711 Fitchburg, USA;Center for Medical Radiation Physics, University of Wollongong, Wollongong, NSW 2522, Australia

关键词: Automatic contour propagation;    NSCLC;    Adaptive radiotherapy;    Deformable image registration;   

Others  :  1152670
DOI  :  10.1186/1748-717X-8-243

 received in 2013-07-10, accepted in 2013-09-28,  发布年份 2013

【 摘 要 】

Background

Deformable image registration (DIR) is an attractive method for automatic propagation of regions of interest (ROIs) in adaptive lung radiotherapy. This study investigates DIR for automatic contour propagation in adaptive Non Small Cell Lung Carcinoma patients.

Methods

Pre and mid-treatment fan beam 4D-kVCT scans were taken for 17 NSCLC patients. Gross tumour volumes (GTV), nodal-GTVs, lungs, esophagus and spinal cord were delineated on all kVCT scans. ROIs were propagated from pre- to mid-treatment images using three DIR algorithms. DIR-propagated ROIs were compared with physician-drawn ROIs on the mid-treatment scan using the Dice score and the mean slicewise Hausdorff distance to agreement (MSHD). A physician scored the DIR-propagated ROIs based on clinical utility.

Results

Good agreement between the DIR-propagated and physician drawn ROIs was observed for the lungs and spinal cord. Agreement was not as good for the nodal-GTVs and esophagus, due to poor soft-tissue contrast surrounding these structures. 96% of OARs and 85% of target volumes were scored as requiring no or minor adjustments.

Conclusions

DIR has been shown to be a clinically useful method for automatic contour propagation in adaptive radiotherapy however thorough assessment of propagated ROIs by the treating physician is recommended.

【 授权许可】

   
2013 Hardcastle et al.; licensee BioMed Central Ltd.

【 图 表 】

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