Toxoplasma gondii infection in interstate truck drivers: a case–control seroprevalence study

Particle and Fibre Toxicology

Oliver Liesenfeld²  Elizabeth Rábago-Sánchez³  Luis Omar Berumen-Segovia⁴  Luis Francisco Sánchez-Anguiano¹  Misael Salcedo-Jáquez⁴  Jesús Hernández-Tinoco¹  Sandy Janet Pacheco-Vega⁴  Cosme Alvarado-Esquivel⁴ 

[1] Institute for Scientific Research “Dr. Roberto Rivera Damm”, Juárez University of Durango State, Avenida Universidad S/N, Durango, 34000, Durango, Mexico;Current address: Medical and Scientific Affairs, Roche Molecular Systems, Pleasanton 94588, CA, USA;General Hospital, Secretary of Health, Avenida 5 de febrero 220, Durango, 34000, Mexico;Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, Durango, 34000, Dgo, Mexico

关键词: Risk factors;    Case–control study;    Truck drivers;    Seroprevalence;    Toxoplasma gondii;   

Others  :  1181827
DOI  :  10.1186/s13071-015-0690-z

 received in 2014-09-28, accepted in 2015-01-23,  发布年份 2015

【 摘 要 】

Background

Infection with Toxoplasma gondii can be acquired via the ingestion of undercooked or raw meat containing tissue cysts, or via ingestion of water contaminated with oocysts. Professional long distance truck driving may have epidemiological importance for food-borne infections since drivers eat out of home and in places where hygiene and cooking practices are uncertain. We aimed to determine whether interstate truck drivers in Durango, Mexico have an increased risk of infection with T. gondii as indicated by seropositivity; and to determine the socio-demographic, work, clinical, and behavioral characteristics associated with T. gondii seropositivity in interstate truck drivers.

Methods

Through a case–control study design, 192 truck drivers and 192 controls from the general population of the same region matched by gender and age were examined with enzyme-linked immunoassays for the presence of anti-Toxoplasma IgG and IgM antibodies. Socio-demographic, work, clinical and behavioral characteristics from the truck drivers were obtained.

Results

Anti-T. gondii IgG antibodies were found in 23 (12.0%) of 192 truck drivers and in 13 (6.8%) of 192 controls (OR = 21.0; 95% CI: 1.23-358.38; P = 0.002). Anti-T. gondii IgM antibodies were found in 7 (3.6%) cases and in 7 (3.6%) controls (P = 1.00). The seroprevalence of T. gondii infection was higher in drivers with reflex impairment than in those without this impairment (4/13, 30.8% vs 19/179, 10.6%, respectively; P = 0.05), and in drivers with hearing impairment than in those without this impairment (3/7, 42.9% vs 20/185, 10.8%, respectively; P = 0.03). Multivariate analysis of work and behavioral characteristics of truck drives showed positive associations of T. gondii exposure with trips to the south of Mexico (OR = 3.11; 95% CI: 1.02-9.44; P = 0.04) and consumption of horse meat (OR = 5.18; 95% CI: 1.62-16.55; P = 0.005).

Conclusions

Results suggest that interstate truck drivers may have an increased risk for T. gondii infection, and that T. gondii exposure may be impacting neurological functions in truck drivers. Contributing factors for T. gondii exposure should be taken into account for the design of optimal prevention measures against T. gondii infection.

【 授权许可】

   
2015 Alvarado-Esquivel et al.; licensee BioMed Central.

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