Characterization of Farmington virus, a novel virus from birds that is distantly related to members of the family Rhabdoviridae

Virology Journal

Robert B Tesh⁶  Nikos Vasilakis⁶  W Ian Lipkin⁴  Peter J Walker²  Vsevolod L Popov⁶  Kelly DeToy⁴  Hilda Guzman⁵  Amelia P A Travassos da Rosa⁵  Nazir Savji³  Naomi L Forrester⁶  Gustavo Palacios¹ 

[1] Center for Genomic Sciences, United States Army Medical Research Institute for Infectious Diseases, Frederick, MD 10032, USA;CSIRO Animal, Food and Health Sciences, Australian Animal Health Laboratory, Geelong, VIC 3220, Australia;Current address: School of Medicine, New York University, New York, NY 10032, USA;Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA;Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, USA;Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0610, USA

关键词: Phylogeny;    Next generation sequencing;    Family Rhabdoviridae;    Farmington virus (FARV);   

Others  :  1149155
DOI  :  10.1186/1743-422X-10-219

 received in 2013-04-08, accepted in 2013-06-26,  发布年份 2013

【 摘 要 】

Background

Farmington virus (FARV) is a rhabdovirus that was isolated from a wild bird during an outbreak of epizootic eastern equine encephalitis on a pheasant farm in Connecticut, USA.

Findings

Analysis of the nearly complete genome sequence of the prototype CT AN 114 strain indicates that it encodes the five canonical rhabdovirus structural proteins (N, P, M, G and L) with alternative ORFs (> 180 nt) in the N and G genes. Phenotypic and genetic characterization of FARV has confirmed that it is a novel rhabdovirus and probably represents a new species within the family Rhabdoviridae.

Conclusions

In sum, our analysis indicates that FARV represents a new species within the family Rhabdoviridae.

【 授权许可】

   
2013 Palacios et al.; licensee BioMed Central Ltd.

【 图 表 】

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