Erythrocyte membrane fatty acid profile and saturation index in gallbladder carcinogenesis: a case-control study

World Journal of Surgical Oncology

Vijay K Shukla³  Shailesh Singh²  Lal B Sharma³  Manoj Pandey¹ 

[1] Department of Surgical Oncology, Regional Cancer Centre, Thiruvananthapuram, 695 011, Kerala, India;Current address Department of Microbiology & Immunology, Morehouse School of Medicine, 720 Westview Drive, SW Atlanta, GA 30310, USA;Department of Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India

关键词: delta 9 desaturase;    signal transduction;    lipid bilayer;    gallstones;    lipid peroxidation;    arachidonic acid;    oleic acid;    stearic acid;    fatty acid;    carcinogenesis;    gallbladder;   

Others  :  1207516
DOI  :  10.1186/1477-7819-1-5

 received in 2003-02-12, accepted in 2003-05-07,  发布年份 2003

【 摘 要 】

Background

Gallbladder cancer is a common neoplasm of biliary tract, with an unknown etiology.

Patients and methods

This study was carried out to evaluate the changes in the membrane fatty acid profile and saturation index in patients with gallbladder cancer. The study sample consisted of 50 newly diagnosed cases of gallbladder cancer and 50 patients undergoing cholecystectomy for cholelithiasis were recruited as controls. The fatty acid estimation was carried out by high performance liquid chromatography (HPLC). Statistical analysis was carried out by student 't' test and one-way ANOVA. Pearson's correlation coefficient was also obtained.

Results

A significant lowering of erythrocyte membrane stearic acid (p = 0.000), arachidonic acid (p = 0.001), and saturation index (p = 0.001) was observed in patients with gallbladder cancer compared to controls. A significant inverse relation was observed between stearic and oleic acid (r = -0.269 p = 0.007).

Conclusion

Results of the present study suggest an increase in the delta 9 desaturation in cancer patients compared to controls however, a possible role of biliary stasis due to altered gallbladder motility or derangements of signal transduction secondary to altered membrane lipid bilayer cannot be ruled out.

【 授权许可】

   
2003 Pandey et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.

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