Severe acute exacerbation of chronic hepatitis B during pegylated interferon treatment and early intervention with corticosteroid

Virology Journal

Xu-Qing Zhang¹  Jian-Ping You¹  Hui-Yan Zhang¹  Qing Mao¹ 

[1] Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, 400038, People's Republic of China

关键词: Pegylated interferon;    Corticosteroid;    Severe acute exacerbation;    Acute-on-chronic liver failure;    Chronic hepatitis B;   

Others  :  1154344
DOI  :  10.1186/1743-422X-9-136

 received in 2011-12-30, accepted in 2012-07-24,  发布年份 2012

【 摘 要 】

Severe acute exacerbation or liver failure induced by standard interferon-α(IFN-α) therapy had been reported to occur in few patients with chronic hepatitis B. However, no report showed that pegylated interferon-α therapy was able to induce severe acute exacerbation of chronic hepatitis B. Here, we describe three patients with severe acute exacerbation of chronic hepatitis B during pegylated interferon-α2a (Pegasys) treatment. One patient progressed into acute-on-chronic liver failure (ACLF) at the second week of Pegasys treatment. Two patients progressed into acute-on-chronic pre-liver failure (pre-ACLF) at the second and eighth week of Pegasys treatment, respectively. Three patients recovered after early combined intervention with corticosteroid and lamivudine. Our data indicated that there was a risk of severe acute exacerbation among patients with chronic hepatitis B during receiving Pegasys treatment. Importantly, early combined intervention with corticosteroid and lamivudine should be introduced to prevent the disease progression and improve their prognosis once severe acute exacerbation was diagnosed.

【 授权许可】

   
2012 Mao et al.; licensee BioMed Central Ltd.

【 图 表 】

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