The intake of maqui (Aristotelia chilensis) berry extract normalizes H2O2 and IL-6 concentrations in exhaled breath condensate from healthy smokers - an explorative study

Nutrition Journal

Martin Gotteland¹  Andrés Sánchez¹  Catalina Carrasco-Pozo¹  Elizabeth Escobar¹  Daniela Ávila¹  Daniela Vergara¹ 

[1] Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Independencia 1027, Independencia, Santiago, Chile

关键词: Inflammation;    Oxidative stress;    Respiratory diseases;    Anthocyanins;    Aristotelia chilensis;    Exhaled breath condensate;    IL-6;    H2O2;    Smokers;   

Others  :  1139647
DOI  :  10.1186/s12937-015-0008-1

 received in 2014-10-17, accepted in 2015-02-13,  发布年份 2015

【 摘 要 】

Background

Respiratory diseases are associated with pulmonary oxidative stress and inflammatory processes. Though studies in animal models suggest that dietary polyphenols improve lung injury, no intervention studies were carried out in humans. The aim of this study was to determine whether the intake of an anthocyanin-rich maqui extract improved H₂O₂ and IL-6 concentrations in exhaled breath condensates (EBCs) from asymptomatic smokers.

Findings

15 asymptomatic smokers with mild cigarette smoking (3 pack-year [2.4 - 7.7]) (mean [CI_95%]) were recruited in this exploratory longitudinal study. They ingested 2 g of maqui extract (polyphenol content = 5.18 ± 2.00 g GAE/100 g; FRAP value = 27.1 ± 2.0 mmol Fe⁺⁺/100 g), twice daily for two weeks. EBCs were collected before and after treatment and the changes in H₂O₂ and IL-6 concentrations were determined by fluorimetry and Elisa, respectively. The EBC contents of H₂O₂ and IL-6 H₂O₂ before and after treatment in smokers were also compared with those determined in single EBC samples from 8 healthy non-smokers subjects. At baseline, the H₂O₂ concentrations were higher and those of IL-6 lower in the smokers than in the non-smokers. Maqui extract significantly decreased H₂O₂ (p < 0.0002) and increased IL-6 (p < 0.004) in the EBC from smokers. The EBC concentrations of H₂O₂ and IL-6 after maqui administration did not differ between smokers and non-smokers.

Conclusions

Maqui extract normalizes IL-6 and H₂O₂ concentrations in EBC from humans with mild smoking habits. If confirmed, these results suggest that dietary polyphenols might be considered as an interesting alternative for the dietary management of respiratory disorders.

【 授权许可】

   
2015 Vergara et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

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