Action mechanism and cardiovascular effect of anthocyanins: a systematic review of animal and human studies

Journal of Translational Medicine

Review

Rafaelli de Souza Gomes¹  Glauber Vilhena da Costa¹  Marta Chagas Monteiro¹  Jordano Ferreira Reis²  Matheus Moraes do Carmo²  Valter Vinicius Silva Monteiro²  Paula Cardoso Ribera² 

[1] Pharmaceutical Science Post-Graduation Program, Health Science Institute, Federal University of Pará/UFPA, 66075900, Belém, PA, Brazil;School of Pharmacy, Health Science Institute, Federal University of Pará/UFPA, 66075900, Belém, PA, Brazil;

关键词: Anthocyanins;    Oxidative stress;    Cardiovascular disease;    Polyphenols;    Animal models;    Human study;   

DOI  :  10.1186/s12967-016-1076-5

 received in 2016-08-10, accepted in 2016-11-08,  发布年份 2016

来源: Springer

【 摘 要 】

Cardiovascular diseases (CVD) are an important cause of death worldwide. Anthocyanins are a subgroup of flavonoids found in berries, flowers, fruits and leaves. In epidemiological and clinical studies, these polyphenols have been associated with improved cardiovascular risk profiles as well as decreased comorbidities. Human intervention studies using berries, vegetables, parts of plants and cereals (either fresh or as juice) or purified anthocyanin-rich extracts have demonstrated significant improvements in low density lipoproteins oxidation, lipid peroxidation, total plasma antioxidant capacity, and dyslipidemia as well as reduced levels of CVD molecular biomarkers. This review discusses the use of anthocyanins in animal models and their applications in human medicine, as dietary supplements or as new potent drugs against cardiovascular disease.

【 授权许可】

CC BY   
© The Author(s) 2016