Testicular yolk sac tumors in children: a review of 61 patients over 19 years

World Journal of Surgical Oncology

Guanghui Wei³  Peng Lu²  Yi Hua²  Xing Liu²  Junhong Liu²  Xuliang Li³  Dawei He²  Tao Lin²  Shengde Wu²  Yi Wei¹ 

[1] Department of Pediatric Surgery, Children's Hospital of Chongqing Medical University, Chongqing, China;Department of Respiratory Medicine, Children’s Hospital, Chongqing Medical University, Chongqing, China;Department of Pathology, Children’s Hospital of Chongqing Medical University, Chongqing, China

关键词: Chemotherapy;    Resection;    Diagnosis;    Testicular yolk sac tumor;    Pediatric;   

Others  :  1146708
DOI  :  10.1186/1477-7819-12-400

 received in 2014-10-16, accepted in 2014-12-05,  发布年份 2014

【 摘 要 】

Background

To describe 19 years of clinical experience managing pediatric patients with testicular yolk sac tumors at the Chongqing Medical University Affiliated Children’s Hospital.

Methods

This study involved a retrospective review of the records of 61 pediatric patients who presented with testicular yolk sac tumor at our institution between 1995 and 2014.

Results

All patients presented with a painless scrotal mass. Serum alpha-fetoprotein (AFP) levels were elevated (n = 15). Ultrasonography identified the yolk sac tumors as solid masses. Color Doppler flow imaging showed rich blood flow inside and around the masses in 84.8% cases. X-ray of the scrotum showed no intrascrotal calcification (n = 38). Inguinal orchiectomy was performed in 60 patients, one case was treated with testis-sparing surgery. In 11 cases, radical dissection of the inguinal lymph nodes was performed. Histological analysis showed pathologies typical of yolk sac tumor including microcapsule and reticular structures, gland tube-gland bubble structures, an embryo sinus structure, and papillary structures. All patients received postoperative chemotherapy. Serum AFP levels returned to normal 1 to 2 months after surgery. No patients treated with surgery in our hospital relapsed.

Conclusion

Testicular yolk sac tumor presents as a painless scrotal mass, increased serum AFP levels, and a solid mass on ultrasound. Chest radiography and abdominal ultrasound should be used to accurately stage the tumor. We advocate for inguinal orchiectomy for Stage I disease and postoperative chemotherapy to prevent recurrence in the ipsilateral or contralateral testis.

【 授权许可】

   
2015 Wei et al.; licensee BioMed Central.

【 图 表 】

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