Cardio-metabolic and immunological impacts of extra virgin olive oil consumption in overweight and obese older adults: a randomized controlled trial

Nutrition & Metabolism

Simin Nikbin Meydani²  Mohsen Meydani²  Yu-Chi Lee²  José M. Ordovás²  Ascensión Marcos¹  Junpeng Wang²  Lijun Li²  Thomas Wilson³  Edward Saltzman²  Garry Handelman³  Dayong Wu²  Junaidah Barnett²  Mitra Rozati³ 

[1] Institute of Food Science and Technology and Nutrition (ICTAN), Scientific National Research Council (CSIC), Madrid, Spain;Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston 02111, MA, USA;Department of Health and Clinical Sciences, University of Massachusetts, Lowell 3 Solomont Way, Suite 4, Lowell 01854, MA, USA

关键词: Obesity;    Aging;    Cardio-metabolic;    Immune response;    Olive oil;   

Others  :  1222344
DOI  :  10.1186/s12986-015-0022-5

 received in 2015-06-03, accepted in 2015-07-21,  发布年份 2015

【 摘 要 】

Background

Both aging and obesity are related to dysregulated immune function, which may be responsible for increased risk of infection and also chronic non-infectious diseases. Dietary lipids have been shown to impact immune and inflammatory responses and cardio-metabolic risk factors. No information on the impact of olive oil on immune responses of overweight and obese older adults is available.

Objective

We aimed to determine the effect of replacing oils used in a typical American diet with extra virgin olive oil for 3 months on immune responses and cardio-metabolic risk factors in overweight and obese older adults.

Methods

This was a randomized, single-blinded and placebo-controlled trial in 41 overweight or obese participants (aged ≥ 65) who consumed a typical American diet. Participants in the control (CON, n = 21) group were provided with a mixture of corn, soybean oil and butter, and those in the olive oil (OO, n = 20) group, with extra virgin olive oil, to replace substitutable oils in their diet. At baseline and 3 months, we measured blood pressure, biochemical and immunological parameters using fasting blood, and delayed-type hypersensitivity (DTH) skin response.

Results

Compared to the CON group, the OO group showed decreased systolic blood pressure (P < 0.05), a strong trend toward increased plasma HDL-C concentrations (P = 0.06), and increased anti-CD3/anti-CD28 -stimulated T cell proliferation (P < 0.05). No differences were found in T cell phenotype, cytokine production, and DTH response between the two groups.

Conclusions

Our results indicate that substitution of oils used in a typical American diet with extra virgin olive oil in overweight and obese older adults may have cardio-metabolic and immunological health benefits. This trial was registered at clinicaltrials.gov as NCT01903304.

【 授权许可】

   
2015 Rozati et al.

【 图 表 】

Fig. 1.

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