Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds

Nutrition Journal

Peter JH Jones⁴  Jiri Frohlich⁸  Philip W Connelly⁶  Lawrence A Leiter³  Robert G Josse¹  Edward Vidgen³  Russell J de Souza⁷  Korbua Srichaikul³  Balachandran Bashyam³  Darshna Patel³  Shahad Abdulnour²  Chris Ireland³  Patrick Couture⁵  Luba Cermakova⁸  Dorothea Faulkner³  Cyril WC Kendall³  Benoit Lamarche⁵  David JA Jenkins¹  Vanu R Ramprasath⁴ 

[1] Faculty of Medicine, University of Toronto, Toronto, ON, Canada;Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada;Departments of Nutritional Sciences, University of Toronto, Toronto, ON, Canada;Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada;Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec;Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, ON, Canada;Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada;Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia

关键词: Portfolio diet;    Fat soluble vitamins;    Plant sterols;   

Others  :  1132459
DOI  :  10.1186/1475-2891-13-101

 received in 2014-06-10, accepted in 2014-10-07,  发布年份 2014

【 摘 要 】

Background

Consumption of a cholesterol lowering dietary portfolio including plant sterols (PS), viscous fibre, soy proteins and nuts for 6 months improves blood lipid profile. Plant sterols reduce blood cholesterol by inhibiting intestinal cholesterol absorption and concerns have been raised whether PS consumption reduces fat soluble vitamin absorption.

Objective

The objective was to determine effects of consumption of a cholesterol lowering dietary portfolio on circulating concentrations of PS and fat soluble vitamins.

Methods

Using a parallel design study, 351 hyperlipidemic participants from 4 centres across Canada were randomized to 1 of 3 groups. Participants followed dietary advice with control or portfolio diet. Participants on routine and intensive portfolio involved 2 and 7 clinic visits, respectively, over 6 months.

Results

No changes in plasma concentrations of α and γ tocopherol, lutein, lycopene and retinol, but decreased β-carotene concentrations were observed with intensive (week 12:p = 0.045; week 24:p = 0.039) and routine (week 12:p = 0.031; week 24:p = 0.078) portfolio groups compared to control. However, cholesterol adjusted β-carotene and fat soluble compound concentrations were not different compared to control. Plasma PS concentrations were increased with intensive (campesterol:p = 0.012; β-sitosterol:p = 0.035) and routine (campesterol: p = 0.034; β-sitosterol: p = 0.080) portfolio groups compared to control. Plasma cholesterol-adjusted campesterol and β-sitosterol concentrations were negatively correlated (p < 0.001) with total and LDL-C levels.

Conclusion

Results demonstrate that consuming a portfolio diet reduces serum total and LDL-C levels while increasing PS values, without altering fat soluble compounds concentrations. The extent of increments of PS with the current study are not deleterious and also maintaining optimum levels of fat soluble vitamins are of paramount necessity to maintain overall metabolism and health. Results indicate portfolio diet as one of the best options for CVD risk reduction.

Trial registration

clinicaltrials.gov Identifier: NCT00438425

【 授权许可】

   
2014 Ramprasath et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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