期刊论文详细信息
Arquivos de Gastroenterologia
Nutritional status of patients with biliary atresia and autoimmune hepatitis related to serum levels of vitamins A, D and E
Margareth L. G. Saron2  Helena T. Godoy1  Gabriel Hessel2 
[1] ,Universidade Estadual de Campinas Department of Pediatrics Campinas SP ,Brazil
关键词: Nutritional status;    Fat soluble vitamins;    Biliary atresia;    Hepatitis;    autoimmune;    Child;    Estado nutricional;    Vitaminas lipossolúveis;    Atresia biliar;    Hepatite autoimune;    Criança;   
DOI  :  10.1590/S0004-28032009000100016
来源: SciELO
PDF
【 摘 要 】

CONTEXT: Chronic liver disease may induce to malabsorption of lipids and fat-soluble vitamins, leading to injury of nutritional status. OBJECTIVES: To evaluate the nutritional status of pediatric-age patients with autoimmune hepatitis and biliary atresia related to serum levels of vitamins A, D and E and the disease severity. METHODS: This controlled transverse study, evaluated the patients with autoimmune hepatitis and biliary atresia and a reference group paired by sex and age. The patients underwent anthropometric evaluation, alimentary inquiry and determination of serum levels of vitamins A, D and E by high performance liquid chromatography. The Mann-Whitney test, Spearman correlation coefficients and variance analysis (ANOVA) were utilized for data treatment, regarding significant difference if P<0.05. RESULTS: The highest nutritional deficit was observed in patients with biliary atresia, mainly with cholestasis. The serum levels of vitamins A and E for the reference group changed as a function of age. The serum levels of vitamins A, D and E were higher in reference group than in patients with biliary atresia and autoimmune hepatitis together or separately. There were not difference in the serum levels of vitamins A, D and E between biliary atresia groups with cholestasis and without cholestasis. It was verified correlation between weight/age, triceps skinfold thickness, subscapular skinfold thickness, midarm circumference, midarm fat area values and vitamin A serum levels, as well as between all anthropometric indicators and vitamin E in patients with autoimmune hepatitis and biliary atresia. CONCLUSION: The patients with biliary atresia and cholestasis presented the highest nutritional injury. The patients with biliary atresia and autoimmune hepatitis presented lower serum levels of vitamins A, D and E that in control group. There is a directly proportional correlation between vitamin serum levels, mainly vitamin E, and all anthropometric variables of biliary atresia and autoimmune hepatitis groups.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

【 预 览 】
附件列表
Files Size Format View
RO202005130004327ZK.pdf 325KB PDF download
  文献评价指标  
  下载次数:8次 浏览次数:15次