Bronchospasm and its biophysical basis in airway smooth muscle

Respiratory Research

Jeffrey J Fredberg¹ 

[1] Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA

关键词: shortening;    bronchoconstriction;    asthma;    lung;    remodeling;    plasticity;    actomyosin;    Myosin;   

Others  :  1227374
DOI  :  10.1186/1465-9921-5-2

 received in 2003-09-03, accepted in 2004-02-26,  发布年份 2004

【 摘 要 】

Airways hyperresponsiveness is a cardinal feature of asthma but remains unexplained. In asthma, the airway smooth muscle cell is the key end-effector of bronchospasm and acute airway narrowing, but in just the past five years our understanding of the relationship of responsiveness to muscle biophysics has dramatically changed. It has become well established, for example, that muscle length is equilibrated dynamically rather than statically, and that non-classical features of muscle biophysics come to the forefront, including unanticipated interactions between the muscle and its time-varying load, as well as the ability of the muscle cell to adapt rapidly to changes in its dynamic microenvironment. These newly discovered phenomena have been described empirically, but a mechanistic basis to explain them is only beginning to emerge.

【 授权许可】

   
2004 Fredberg; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.

【 图 表 】

Figure 1.

Figure 2.

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