Review: Collectins link innate and adaptive immunity in allergic airway disease:

Innate Immunity

Julie G.Ledford¹ 

关键词: surfactant protein;    collectin;    asthma;    inflammation;    lung;   

DOI  :  10.1177/1753425910368446

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Although the lipoprotein complex of pulmonary surfactant has long been recognized as essential for reducing lung surface tension, its role in lung immune host defense has only relatively recently been elucidated. Surfactant-associated proteins A (SP-A) and D (SP-D) can attenuate bacterial and viral infection and inflammation by acting as opsonins and by regulating innate immune cell functions. Surfactant-associated protein A and D also interact with antigen-presenting cells and T cells, thereby linking the innate and adaptive immune systems. A recent study from our laboratory demonstrated that mice deficient in SP-A have enhanced susceptibility to airway hyper-responsiveness and lung inflammation induced by Mycoplasma pneumonia, an atypical bacterium present in the airways of approximately 50% of asthmatics experiencing their first episode, and further supports an important role for SP-A in the host response to allergic airway disease. Animal and human studies suggest that alterations in the functions or ...

【 授权许可】

CC BY