Activation of ATP-sensitive potassium channels antagonize nociceptive behavior and hyperexcitability of DRG neurons from rats

Molecular Pain

Hailin Zhang¹  Chao Wang¹  Xiaona Du¹ 

[1]The Key Laboratory of Neural and Vascular Biology, Ministry of Education

[2] The Key Laboratory of New Drug Pharmacology and Toxicology, Hebei Province

[3] Department of Pharmacology, Hebei Medical University, Shijiazhuang, China

关键词: glyburide;    diazoxide;    pinacidil;    nociception;    excitability;    DRG;    potassium channels;    K_ATP;   

Others  :  865912
DOI  :  10.1186/1744-8069-7-35

 received in 2011-01-12, accepted in 2011-05-14,  发布年份 2011

【 摘 要 】

Background

Nociceptive responses to noxious stimuli are initiated at peripheral nociceptor terminals. Ion channels play a vital role in pain signal initiation and conduction. Activation of K_ATP channels has been implicated in mediating the analgesic effects of agents such as morphine. However, systematic studies regarding the effects of K_ATP activators on nociception and neuronal excitability are scarce.

Results

In this study, we describe the antagonistic effects of K_ATP activators pinacidil and diazoxide on nocifensive behavior induced by bradykinin (BK), thermo and mechanical stimuli, and the bradykinin-induced hyperexcitability of DRG neurons. We also found that K_ATP activators can moderately activate K_ATP in DRG neurons. Because the effects of K_ATP activators can be reversed by the K_ATP blocker glyburide, direct activation of K_ATP is most likely the underlying mechanism.

Conclusion

This systematic study clearly demonstrates that activation of K_ATP could have significant modulatory effects on the excitability of sensory neurons and thus on sensory behaviors, such as nociception. K_ATP activators can be evaluated clinically for the treatment of pain symptoms.

【 授权许可】

   
2011 Du et al; licensee BioMed Central Ltd.

【 图 表 】

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