Insecticidal and repellent activities of pyrethroids to the three major pyrethroid-resistant malaria vectors in western Kenya

Particle and Fibre Toxicology

Noboru Minakawa²  Charles Mwandawiro⁵  Sammy M Njenga⁶  George Sonye⁷  Gabriel O Dida³  Kazunori Ohashi⁴  Hitoshi Kawada¹ 

[1] Department of Vector Ecology & Environment, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan;The Global Center of Excellence Program, Nagasaki University, Nagasaki, Japan;School of Public Health, Maseno University, Kisumu, Kenya;Health and Crop Sciences Research Laboratory, Sumitomo Chemical Co Ltd, Hyogo, Japan;Kenya Medical Research Institute, Nairobi, Kenya;Eastern and Southern Africa Centre of International Parasite Control, Nairobi, Kenya;Springs of Hope, Mbita, Kenya

关键词: Kenya;    LLIN;    Anopheles funestus;    Anopheles arabiensis;    Anopheles gambiae s.s;    Repellency;    Resistance;    Deltamethrin;    Permethrin;   

Others  :  806934
DOI  :  10.1186/1756-3305-7-208

 received in 2014-03-04, accepted in 2014-04-18,  发布年份 2014

【 摘 要 】

Background

The dramatic success of insecticide treated nets (ITNs) and long-lasting insecticidal nets (LLINs) in African countries has been countered by the rapid development of pyrethroid resistance in vector mosquitoes over the past decade. One advantage of the use of pyrethroids in ITNs is their excito-repellency. Use of the excito-repellency of pyrethroids might be biorational, since such repellency will not induce or delay the development of any physiological resistance. However, little is known about the relationship between the mode of insecticide resistance and excito-repellency in pyrethroid-resistant mosquitoes.

Methods

Differences in the reactions of 3 major malaria vectors in western Kenya to pyrethroids were compared in laboratory tests. Adult susceptibility tests were performed using World Health Organization (WHO) test tube kits for F1 progenies of field-collected An. gambiae s.s., An. arabiensis, and An. funestus s.s., and laboratory colonies of An. gambiae s.s. and An. arabiensis. The contact repellency to pyrethroids or permethrin-impregnated LLINs (Olyset® Nets) was evaluated with a simple choice test modified by WHO test tubes and with the test modified by the WHO cone bioassay test.

Results

Field-collected An. gambiae s.s., An. arabiensis, and An. funestus s.s. showed high resistance to both permethrin and deltamethrin. The allelic frequency of the point mutation in the voltage-gated sodium channel (L1014S) in An. gambiae s.s. was 99.3–100%, while no point mutations were detected in the other 2 species. The frequency of takeoffs from the pyrethroid-treated surface and the flying times without contacting the surface increased significantly in pyrethroid-susceptible An. gambiae s.s. and An. arabiensis colonies and wild An. arabiensis and An. funestus s.s. colonies, while there was no significant increase in the frequency of takeoffs or flying time in the An. gambiae s.s. wild colony.

Conclusion

A different repellent reaction was observed in the field-collected An. gambiae s.s. than in An. arabiensis and An. funestus s.s. It might be that resistant mosquitoes governed by knockdown resistance (kdr) loose repellency to pyrethroids, whereas those lacking kdr maintain high repellency irrespective of their possessing metabolic resistance factors to pyrethroids. Further genetic evaluation is required for the demonstration of the above hypothesis.

【 授权许可】

   
2014 Kawada et al.; licensee BioMed Central Ltd.

【 图 表 】

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