期刊论文详细信息
Nutrition Journal
Adiposity markers and risk of coronary heart disease in patients with type 2 diabetes mellitus
Jussara C Almeida2  Luis Henrique S Canani2  Mirela J Azevedo2  Juliana P Antonio1  Flávia M Silva1  Simone F Tonding1 
[1] Graduate Program in Medical Sciences: Endocrinology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;Department of Internal Medicine, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
关键词: Type 2;    Diabetes mellitus;    Coronary disease;    Abdominal;    Obesity;    Body fat distribution;    Anthropometry;   
Others  :  1132383
DOI  :  10.1186/1475-2891-13-124
 received in 2014-06-04, accepted in 2014-12-05,  发布年份 2014
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【 摘 要 】

Background

This cross-sectional study aimed to evaluating the association between body adiposity markers and high-risk of coronary heart disease (CHD) in patients with type 2 diabetes.

Methods

Recent adiposity markers [waist-to-height ratio, conicity index (C-index) and body adiposity index] and traditional markers [BMI, waist circumference and waist-to-hip ratio (WHR)] were measured. The 10-year risk of fatal CHD was estimated according to UKPDS risk engine scores. Patients were divided into high (CHD risk ≥20%; n = 99) or low-moderate (CHD risk <20%; n = 321) risk groups. Multiple logistic regression models were performed to analyze associations between CHD risk (outcome) and adiposity markers.

Results

A total of 420 patients with type 2 diabetes (61.9 ± 9.5 years; 53.5% females; HbA1c 7.6 ± 1.6%) were evaluated. The high risk group had greater proportions of elevated C-index and BMI values than patients with low-moderate risk. No between-group differences in other adiposity markers were observed. In multiple logistic regression models, only C-index values ≥1.35 were associated with CHD risk >20% (OR = 1.69; 95% CI 1.03-2.78; P = 0.039) after adjusting for confounders (sedentary lifestyle, diabetic nephropathy, serum creatinine, and diabetes duration). The association between WHR and CHD risk did not hold in this sample.

Conclusions

The C-index was the body adiposity marker best associated with high risk of fatal CHD in these patients with type 2 diabetes.

【 授权许可】

   
2014 Tonding et al.; licensee BioMed Central.

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