Associations between hepatitis B virus basal core promoter/pre-core region mutations and the risk of acute-on-chronic liver failure: a meta-analysis

Virology Journal

Jifang Sheng²  Yu Shi²  Huadong Yan¹  Sheng Bi²  Feishu Hu² 

[1] Department of Hepatology, Ningbo No. 2 Hospital, Ningbo 315010, China;State Key Lab of Diagnostic and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital of Medical School, Zhejiang University, Hangzhou 310000, China

关键词: Hepatitis B e antigen;    Acute-on-chronic liver failure;    Mutation;    Hepatitis B virus;   

Others  :  1224927
DOI  :  10.1186/s12985-015-0313-5

 received in 2014-10-16, accepted in 2015-05-25,  发布年份 2015

【 摘 要 】

Background

Several studies have suggested a relationship between hepatitis B virus (HBV) basal core promoter/pre-core mutations and HBV-induced acute-on-chronic liver failure (ACLF). Therefore, we evaluated this potential relationship using a meta-analysis.

Methods

Chinese or English studies from 1966 to January 31, 2014 were included in the analysis. A random or fixed-effects model was used to merge the odds ratios (ORs).

Results

We identified 31 case–control studies containing a total population of 1995 ACLF and 3822 chronic hepatitis B (CHB) patients. Several mutations were significantly correlated with ACLF: T1753V (1.889, 95 % confidence interval (CI) [1.357–2.631]), A1762T (2.696 [2.265–3.207]), G1764A (3.005 [2.077–4.347]), A1762T/G1764A (2.379 [1.519–3.727]), C1766T (1.849 [1.403–2.437]), T1768A (2.440 [1.405–3.494]), A1846T (3.163 [2.157–4.639]), G1896A (2.181 [1.800–2.642]), G1899A (3.569 [2.906–4.385]) and G1896A/A1762T/G1764A (1.575 [1.172–2.116]). Additionally, HBeAg-negative status was also statistically significant for the progression to ACLF (OR = 2.813, 95 % CI = 2.240–3.533, p < 0.001). However, there was no association between ACLF development and HBV genotype.

Conclusions

The HBV basal core promoter/pre-core mutations T1753V, A1762T, G1764A, C1766T, T1768A, A1846T, G1896A and G1899A, and an HBeAg-negative status correlate with an increased risk of HBV-ACLF.

【 授权许可】

   
2015 Hu et al.

【 图 表 】

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