Comparative evaluation of the prophylactic activity of a slow-release insecticide collar and a moxidectin spot-on formulation against Thelazia callipaeda infection in naturally exposed dogs in France

Particle and Fibre Toxicology

Jacques Guillot⁵  Christophe Lesueur³  Sabine Chahory²  Loïc Desquilbet⁶  Olivier Pennant¹  Noémie Siméon⁴  Charlotte Lechat⁵ 

[1] Veterinary Clinic, Vergt, France;Ophthalmology, Ecole nationale vétérinaire d’Alfort, Maisons-Alfort, France;Bayer Animal Health, Puteaux, France;Veterinary Clinic, Notre Dame de Sanilhac, France;Parasitology, Ecole nationale vétérinaire d’Alfort, Maisons-Alfort, France;Biostatistics and clinical epidemiology, Ecole nationale vétérinaire d’Alfort, Maisons-Alfort, France

关键词: France;    Dog;    Prevention;    Eyeworm;    Thelazia callipaeda;   

Others  :  1146940
DOI  :  10.1186/s13071-015-0696-6

 received in 2014-10-17, accepted in 2015-01-26,  发布年份 2015

【 摘 要 】

Background

The relative efficacy of a collar containing 10% imidacloprid and 4.5% flumethrin (Seresto®, Bayer Animal Health) and a spot on formulation containing 10% imidacloprid and 2.5% moxidectin (Advocate®, Bayer Animal Health) was evaluated as a control measure to prevent canine thelaziosis in dogs in an endemic area of France.

Findings

Ninety-six privately-owned dogs were enrolled in the multicentre, controlled study. Before summer (the period of transmission by fruit flies), dogs were allocated to one of three groups: Group A (n = 36)- treated once with a collar containing 10% imidacloprid and 4.5% flumethrin; Group B (n = 33)- treated every month for 8 months with a spot-on containing imidacloprid 10% and moxidectin 2.5%; and Group C (n = 27)- untreated control animals. Dogs were regularly subjected to ocular examination in order to assess Thelazia callipaeda infection. During the trial, T. callipaeda nematodes were detected in 12 (33%) collared dogs (group A) whereas no eyeworm could be found in dogs who received a monthly spot on application of moxidectin (group B). In the control group, 8 (30%) dogs became infected.

Conclusions

The monthly application of a spot on formulation containing 10% imidacloprid and 2.5% moxidectin was shown to be highly effective in preventing T. callipaeda infection in a population of dogs living in an endemic area in France. On the contrary, the slow-release collar tested in this study did not display any protection against canine thelaziosis.

【 授权许可】

   
2015 Lechat et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

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