Efficacy of an imidacloprid/flumethrin collar against fleas, ticks and tick-borne pathogens in dogs

Particle and Fibre Toxicology

Domenico Otranto⁴  Dorothee Stanneck¹  Edward Breitschwerdt³  Barbara Qurollo³  Giancarlo Di Paola⁴  Viviana Domenica Tarallo⁴  Vita Lacasella⁴  Maria Stefania Latrofa⁴  Anna Sara De Tommasi⁴  Donato de Caprariis⁴  Cinzia Cantacessi²  Riccardo Paolo Lia⁴  Rafael Antonio Nascimento Ramos⁴  Alessio Giannelli⁴  Gioia Capelli⁵  Filipe Dantas-Torres⁶ 

[1] Bayer Animal Health GmbH, Leverkusen, Germany;Center for Biodiscovery and Molecular Development of Therapeutics, James Cook University, Cairns, Australia;Intracellular Pathogens Research Laboratory, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA;Department of Veterinary Medicine, University of Bari, Bari, Valenzano, Italy;Istituto Zooprofilattico Sperimentale delle Venezie, Padova, Legnaro, Italy;Current address: Department of Immunology, Aggeu Magalhães Research Center, Recife, Pernambuco, Brazil

关键词: Tick;    Flumethrin;    Imidacloprid;    Dog;    Prevention;    Hepatozoon canis;    Babesia vogeli;    Anaplasma platys;    Canine vector-borne diseases;   

Others  :  824796
DOI  :  10.1186/1756-3305-6-245

 received in 2013-07-03, accepted in 2013-08-18,  发布年份 2013

【 摘 要 】

Background

Tick-borne diseases comprise a group of maladies that are of substantial medical and veterinary significance. A range of tick-borne pathogens, including diverse species of bacteria and protozoa, can infect both dogs and humans. Hence, the control of tick infestations is pivotal to decrease or prevent tick-borne pathogen transmission. Therefore, different commercial products with insecticidal, repellent or both properties have been developed for use on dogs. Recently, a collar containing a combination of imidacloprid 10% and flumethrin 4.5% has proven effective to prevent tick and flea infestations in dogs under field conditions and the infection by some vector-borne pathogens they transmit under laboratory-controlled conditions.

Methods

From March 2011 to April 2012, a field study was conducted in a private shelter in southern Italy to assess the efficacy of the imidacloprid/flumethrin collar against tick and flea infestations and to determine if this strategy would decrease tick-borne pathogen transmission in young dogs. A total of 122 animals were enrolled in the study and randomly assigned to group A (n = 64; collared) or group B (n = 58; untreated controls). Dogs were examined monthly for ticks and fleas and systematically tested for selected tick-borne pathogens.

Results

Compared to controls, the collar provided overall efficacies of 99.7% and 100% against tick and flea infestation, respectively. The overall efficacy for the prevention of tick-borne pathogens (i.e., Anaplasma platys and Babesia vogeli) was 91.6%.

Conclusions

This study demonstrates that the imidacloprid/flumethrin collar is efficacious against flea and tick infestation as well as tick-borne pathogen transmission to dogs under field conditions.

【 授权许可】

   
2013 Dantas-Torres et al.; licensee BioMed Central Ltd.

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