Validation of the rapid assessment procedure for loiasis (RAPLOA) in the democratic republic of Congo

Particle and Fibre Toxicology

Jan H Remme³  Peter J Diggle⁶  Tony O Ukety⁴  Floribert Tepage²  Maurice N Mutro⁵  Dowo O Akotshi⁷  Samuel Wanji¹ 

[1] Research Foundation for Tropical Diseases and the Environment (REFOTDE), P.O. Box 474, Buea, Cameroon;Programme National de Lutte contre l'Onchocercose, Ministère de la Santé Publique, Buta, République démocratique du Congo;120 Rue des Campanules, 01210 Ornex, France;World Health Organization, Prevention of Blindness and Deafness, Avenue Appia 20, 1211 Geneva 27, Switzerland;Centre de Recherche en Maladies Tropicales de l'Ituri, Hôpital Général de Référence de Rethy, République démocratique du Congo;Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YB, UK;Programme National de Lutte contre l'Onchocercose, Ministère de la Santé Publique, Kinshasa, République démocratique du Congo

关键词: lymphatic filariasis;    onchocerciasis;    ivermectin;    loiasis;    RAPLOA;   

Others  :  1233100
DOI  :  10.1186/1756-3305-5-25

 received in 2011-11-26, accepted in 2012-02-02,  发布年份 2012

【 摘 要 】

Background

A simple method called RAPLOA, to rapidly assess what proportion of people in a community are infected with L. loa and hence which communities are at high risk of severe adverse reactions following ivermectin treatment, was developed in Cameroon and Nigeria. The method needed further validation in other geographical and cultural contexts before its application in all endemic countries. The present study was designed to validate RAPLOA in two regions in the North East and South West of the Democratic Republic of Congo.

Methods

In each study region, villages were selected from different bio-ecological zones in order to cover a wide range of loiasis endemicity. In each selected community, 80 people above the age of 15 years were interviewed for a history of eye worm (migration of adult L. loa under the conjunctiva of the eye) and parasitologically examined for the presence and intensity of L. loa infection. In total, 8100 individuals from 99 villages were enrolled into the study.

Results

The results confirmed the findings of the original RAPLOA study: i) the eye worm phenomenon was well-known in all endemic areas, ii) there was a clear relationship between the prevalence of eye worm history and the prevalence and intensity of L. loa microfilaraemia, and iii) using a threshold of 40%, the prevalence of eye worm history was a sensitive and specific indicator of high-risk communities.

Conclusion

Following this successful validation, RAPLOA was recommended for the assessment of loiasis endemicity in areas targeted for ivermectin treatment by lymphatic filariasis and onchocerciasis control programmes.

【 授权许可】

   
2012 Wanji et al; licensee BioMed Central Ltd.

【 图 表 】

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