期刊论文详细信息
Nutrition Journal
Apple phytochemicals and their health benefits
Rui Hai Liu1  Jeanelle Boyer1 
[1] Department of Food Science and Institute of Comparative and Environmental Toxicology, Cornell University, Ithaca, New York 14853-7201 USA
关键词: fruit;    flavonoids;    phenolics;    cardiovascular disease;    cancer;    phytochemicals;    antioxidants;    apples;   
Others  :  1151933
DOI  :  10.1186/1475-2891-3-5
 received in 2004-01-20, accepted in 2004-05-12,  发布年份 2004
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【 摘 要 】

Evidence suggests that a diet high in fruits and vegetables may decrease the risk of chronic diseases, such as cardiovascular disease and cancer, and phytochemicals including phenolics, flavonoids and carotenoids from fruits and vegetables may play a key role in reducing chronic disease risk. Apples are a widely consumed, rich source of phytochemicals, and epidemiological studies have linked the consumption of apples with reduced risk of some cancers, cardiovascular disease, asthma, and diabetes. In the laboratory, apples have been found to have very strong antioxidant activity, inhibit cancer cell proliferation, decrease lipid oxidation, and lower cholesterol. Apples contain a variety of phytochemicals, including quercetin, catechin, phloridzin and chlorogenic acid, all of which are strong antioxidants. The phytochemical composition of apples varies greatly between different varieties of apples, and there are also small changes in phytochemicals during the maturation and ripening of the fruit. Storage has little to no effect on apple phytochemicals, but processing can greatly affect apple phytochemicals. While extensive research exists, a literature review of the health benefits of apples and their phytochemicals has not been compiled to summarize this work. The purpose of this paper is to review the most recent literature regarding the health benefits of apples and their phytochemicals, phytochemical bioavailability and antioxidant behavior, and the effects of variety, ripening, storage and processing on apple phytochemicals.

【 授权许可】

   
2004 Boyer and Liu; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.

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【 参考文献 】
  • [1]Doll R, Peto R: The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 1981, 66:1191-308.
  • [2]Willett W: Diet, nutrition, and avoidable cancer. Environ Health Perspect 1995, 103:165-170.
  • [3]Woffram S, Block M, Ader P: Quercetin-3-glucoside is transported by the glucose carrier SGLT1 across the brush border membrane of rat small intestines. J Nutr 2002, 132:630-635.
  • [4]Finkelstein EA, Fiebelkorn IC, Wang G: National medical spending attributable to overweight and obesity: how much, and who's paying? Health Aff Millwood 2003, (Suppl W3):219-226.
  • [5]Block G, Patterson B, Subar A: Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer 1992, 18:1-29.
  • [6]Malin A, Qi D, Shu X, Gao Y, Friedmann J, Jin F, Zheng W: Intake of fruits and vegetables and selected micronutrients in relation to the risk of breast cancer. Int J Cancer 2003, 105:413-418.
  • [7]Joshipura K, Hu F, Manson J, Stampfer M, Rimm E, Speizer F, Colditz G, Ascherio A, Rosner B, Spiegelman D, Willett W: The effect of fruit and vegetable intake on risk of coronary heart disease. Ann Intern Med 2001, 134:1106-1114.
  • [8]Woods R, Walters H, Raven J, Wolfe R, Ireland P, Thien F, Abramson M: Food and nutrient intakes and asthma risk in young adults. Am J Clin Nutr 2003, 78:414-421.
  • [9]Willett W: Balancing life-style and genomics research for disease prevention. Science 2002, 296:695-698.
  • [10]Ames B, Shigenaga M, Hagen T: Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci 1993, 90:7915-7922.
  • [11]Hollman P, Katan M: Absorption, metabolism and health effects of dietary flavonoids in man. Biomed Pharmacother 1997, 51:305-310.
  • [12]Liu RH: Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr 2003, 78(3 Suppl):517S-520S.
  • [13]Vinson J, Su X, Zubik L, Bose P: Phenol antioxidant quantity and quality in foods: fruits. J Agric Food Chem 2001, 49:5315-5321.
  • [14]Hertog M, Feskens E, Hollman P, Katan M, Kromhout D: Dietary antioxidant flavonols and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 1993, 342:1007-1111.
  • [15]Knekt P, Jarvinen R, Seppanen R, Heliovaara M, Teppo L, Pukkala E, Aromaa A: Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am J Epidemiol 1997, 146:223-230.
  • [16]Knekt P, Kumpulainen J, Jarvinen R, Rissanen H, Heliovaara M, Reunanen A, Hakulinen T, Aromaa A: Flavonoid intake and risk of chronic diseases. Am J Clin Nutr 2002, 76:560-568.
  • [17]Sun J, Chu Y, Wu X, Liu RH: Antioxidant and antiproliferative activities of common fruits. J Agric Food Chem 2002, 50:7449-7454.
  • [18]Feskanich D, Ziegler R, Michaud D, Giovannucci E, Speizer F, WIllett W, Colditz G: Prospective study of fruit and vegetable consumption and risk of lung cancer among men and women. J Natl Cancer Inst 2000, 92:1812-1823.
  • [19]Le Marchand L, Murphy S, Hankin J, Wilkens L, Kolonel L: Intake of flavonoids and lung cancer. J Natl Canc Inst 2000, 92:154-160.
  • [20]Hollman P, Arts I: Flavonols, flavones, and flavanols-nature, occurrence and dietary burden. J Sci Food Agri 2000, 80:1081-1093.
  • [21]Arts I, Hollman P, Mesquita H, Feskens E, Kromhout D: Dietary catechins and epithelial cancer incidence: the Zutphen Elderly Study. Int J Cancer 2001, 92:298-302.
  • [22]Hertog M, Feskens E, Hollman P, Katan M, Kromhout D: Dietary flavonoids and cancer risk in the Zutphen Elderly study. Nutr Cancer 1994, 22:175-184.
  • [23]Sesso H, Gaziano JM, Liu S, Buring J: Flavonoid intake and risk of cardiovascular disease in women. Am J Clin Nutr 2003, 77:1400-1408.
  • [24]Knekt P, Jarvinen R, Hakkinen R, Reunanen A, Maatela J: Flavonoid intake and coronary mortality in Finland: a cohort study. BMJ 1996, 312:478-481.
  • [25]Knekt P, Isotupa S, Rissanen H, Heliovaara M, Jarvinen R, Hakkinen R, Aromaa A, Reunanen A: Quercetin intake and the incidence of cerebrovascular disease. Eur J Clin Nutr 2000, 54:415-417.
  • [26]Arts I, D. J, Harnack L, Gross M, Folsom A: Dietary catechins in relation to coronary heart disease among postmenopausal women. Epidemiology 2001, 12:668-675.
  • [27]Shaheen S, Sterne J, Thompson R, Songhurst C, Margetts B, Buerney P: Dietary antioxidants and asthma in adults- population based case-control study. Am J Respir Crit Care Med 2001, 164:1823-1828.
  • [28]Tabak C, Arts I, Smit H, Heederik D, Kromhout D: Chronic obstructive pulmonary disease and intake of catechins, flavonols, and flavones. Am J Respir Crit Care Med 2001, 164:61-64.
  • [29]Butland B, Fehily A, Elwood P: Diet, lung function, and lung decline in a cohort of 2512 middle aged men. Thorax 2000, 55:102-108.
  • [30]de Oliviera M, Sichieri R, Moura A: Weight loss associated with a daily intake of three apples or three pears among overweight women. Nutr 2003, 19:253-256.
  • [31]Wolfe K, Wu X, Liu RH: Antioxidant activity of apple peels. J Agric Food Chem 2003, 51:609-614.
  • [32]Eberhardt M, Lee C, Liu RH: Antioxidant activity of fresh apples. Nature 2000, 405:903-904.
  • [33]Liu RH, Eberhardt M, Lee C: Antioxidant and antiproliferative activities of selected New York apple cultivars. New York Fruit Quarterly 2001, 9:15-17.
  • [34]Lapidot T, Walker M, Kanner J: Can apple antioxidants inhibit tumor cell proliferation? generation of H2O2 during interaction of phenolic compounds with cell culture media. J Agric Food Chem 2002, 50:3156-3160.
  • [35]Liu RH, Sun J: Antiproliferative activity of apples is not due to phenolic-induced hydrogen peroxide formation. J Agric Food Chem 2003, 51:1718-1723.
  • [36]Mayer B, Schumacher M, Branstatter H, Wagner F, Hermetter A: High-throughput flourescence screening of antioxidative capacity in human serum. Analyt Biochem 2001, 297:144-153.
  • [37]Pearson D, Tan C, German B, Davis P, Gershwin M: Apple juice inhibits low density lipoprotein oxidation. Life Sci 1999, 64:1919-1920.
  • [38]Breinholt V, Nielson S, Knuthsen P, Lauridsen S, Daneshvar B, Sorensen A: Effects of commonly consumed fruit juices and carbohydrates on redox status and anticancer biomarkers in female rats. Nutr Cancer 2003, 45:46-52.
  • [39]Young J, Nielson S, Haraldsdottir J, Daneshvar B, Lauridsen S, Knuthsen P, Crozier A, Sandstrom B, Dragsted L: Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status. Am J Clin Nutr 1999, 69:87-94.
  • [40]Aprikian O, Levrat-Verny M, Besson C, Busserolles J, Remesy C, Demigne C: Apple favourably affects parameters of cholesterol metabolism and of anti-oxidative protection in cholesterol fed rats. Food Chem 2001, 75:445-452.
  • [41]Leontowicz H, Gorinstein S, Lojek A, Leontowicz M, Ciz M, Soliva-Fortuny R, Park Y, Jung S, Trakhtenberg S, Martin-Belloso O: Comparative content of some bioactive compounds in apples, peaches, and pears and their influence on lipids and antioxidant capacity in rats. J Nutr Biochem 2002, 13:603-610.
  • [42]Aprikian O, Busserolles J, Manach C, Mazur A, Morand C, Davicco M, Besson C, Rayssiguier Y, Remesy C, Demigne C: Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese Zucker rats. J Nutr 2002, 132:1969-1976.
  • [43]Leontowicz M, Gorinstein S, Bartnikowska E, Leontowicz H, Kulasek G, Trakhtenberg S: Sugar beet pulp and apple pomace dietary fibers improve lipid metabolism in rats fed cholesterol. Food Chem 2001, 72:73-78.
  • [44]Aprikian O, Duclos V, Guyot S, Besson C, Manach C, Bernalier A, Morand C, Remesy C, Demigne C: Apple pectin and a polyphenol rich apple concentrate are more effective together than separately on cecal fermentations and plasma lipids inrats. J Nutr 2003, 133:1860-1865.
  • [45]Saito T, Miyake M, Toba M, Okamatsu H, Shimizu S, Noda M: Inhibition by apple polyphenols of ADP-ribotransferase activity of cholera toxin and toxin-induced fluid accumulation in mice. Microbiol Immunol 2002, 46:249-55.
  • [46]Lee K, Kim Y, Kim D, Lee H, Lee C: Major phenolics in apple and their contribution to the total antioxidant capacity. J Agric Food Chem 2003, 51:6516-6520.
  • [47]Escarpa A, Gonzalez M: High-performance liquid chromatography with diode-array detection for the performance of phenolic compounds in peel and pulp from different apple varieties. J Chromat A 1998, 823:331-337.
  • [48]Leontowicz M, Gorinstein S, Leontowicz H, Krezeminski R, Lojek A, Katrich E, Ciz M, Martin-Belloso O, Soliva-Fortuny R, Haruenkit R, Trakhtenberg S: Apple and pear peel and pulp and their influences on plasma lipids and antioxidant potential in rats fed cholesterol-containing diets. J Agric Food Chem 2003, 51:5780-5785.
  • [49]da SIlva Porto P, Laranjinha J, de Freitas V: Antioxidant protection of low density lipoprotein by procyanidins: structure/activity relationships. Biochem Pharmacol 2003, 66:947-954.
  • [50]Ebeler SE, Brenneman CA, Kim GS, Jewell WT, Webb MR, Chacon-Rodriguez L, MacDonaold EA, Cramer AC, Levi A, Ebeler JD, Islas-Trejo A, Kraus A, Hinrichs SH, Clifford AJ: Dietary catechin delays tumor onset in a transgenic mouse model. AM J Clin Nutr 2002, 76:865-872.
  • [51]Weyant M, Carothers A, Dannenberg A, Bertagnolli M: Catechin inhibits intestinal tumor formation and suppresses focal adhesion kinase activation in the min/+ mouse. Cancer Res 2001, 61:118-125.
  • [52]Sawa T, Nakao M, Akaike T, Ono K, Maeda H: Alkylperoxyl radical scavenging activity of various flavonoids and other phenolic compounds: implications for the anti-tumor promoter effect of vegetables. J Agric Food Chem 1999, 47:397-402.
  • [53]Kasai H, Fukada S, Yamaizumi Z, Sugie S, Mori H: Action of chlorogenic acid in vegetables and fruits as an inhibitor of 8-hydroxydeoxyguanosine formation in vitro and in a rat carcinogenesis model. Food Chem Toxicol 2000, 38:467-471.
  • [54]Lamson D, Brignall M: Antioxidants and Cancer III: Quercetin. Altern Med Rev 2000, 5:196-209.
  • [55]Peng I, Kuo S: Flavonoid structure affects inhibition of lipid peroxidation in caco-2 intestinal cells at physiological conditions. J Nutr 2003, 2184-2187.
  • [56]Molina M, Sanchez-Reus I, Iglesias I, Benedi J: Quercetin, a flavonoid antioxidant, prevents and protects against ethanol-induced oxidative stress in mouse liver. Biol Pharm Bull 2003, 26:1398-1402.
  • [57]van der Woude H, Gliszcynska-Swiglo A, Struijs K, Smeets A, Alink G, Rietjens I: Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans. Cancer Lett 2003, 200:41-47.
  • [58]Mertens-Talcott S, Talcott S, Percival S: Low concentration of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells. J Nutr 2003, 133:2669-2674.
  • [59]Hubbard G, Wolffram S, Lovegrove J, Gibbins J: The role of polyphenolic compounds in the diet as inhibitors of platelet function. Proc Nutr Soc 2003, 62:469-478.
  • [60]Dupont S, Bennet R, Mellon F, Willamson G: Polyphenols from alcoholic apple cider are absorbed, metabolized, and excreted by humans. J Nutr 2002, 132:172-175.
  • [61]Hollman P, van Trijp J, Buysman M, Gaag M, Mengelers M, de Vries J, Katan M: Relative bioavailability of the various antioxidant flavonoid quercetin from various foods in man. FEBS Let 1997, 418:152-156.
  • [62]Walle T, Otake Y, Walle K, Wilson F: Quercetin glucosides are completely hydrolyzed in ileostomy patients before absorption. J Nutr 2000, 130:2658-2661.
  • [63]Day A, Gee J, Dupont M, Johnson I, Williamson G: Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium dependent glucose transporter. Biochem Pharma 2003, 65:119-1206.
  • [64]Schneider H, Schwiertz A, Collins M, Blaut M: Anaerobic transformation of quercetin-3-glucoside by bacteria from the human intestinal tract. Arch Microbiol 1999, 171:81-91.
  • [65]Crespy V, Aprikian O, Morand C, Besson C, Manach C, Demigne C, Remesy C: Bioavailability of phloretin and phloridzin in rats. J Nutr 2001, 131:3227-3230.
  • [66]Walle T, Walle K: The beta-D-glucoside and sodium-dependent glucose transporter 1 (SGLT1)-inhibitor phloridzin is transported by both SGLT1 and multidrug resistance-associated proteins 1/2. Drug Metab and Dispos 2003, 31:1288-1291.
  • [67]Olthof MR, Hollman PC, Katan MB: Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr 2001, 131:66-71.
  • [68]Gonthier M, Verny M, Besson C, Remesy C, Scalbert A: Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats. J Nutr 2003, 133:1853-1859.
  • [69]Olthof M, Hollman P, Buijsman M, van Amelsvoort J, Katan M: Chlorogenic acid, quercetin-3-rutinoside and black tea polyphenols are extensively metabolized in humans. J Nutr 2003, 133:1806-1814.
  • [70]Spencer J: Metabolism of tea flavonoids in the gastrointestinal tract. J Nutr 2003, 133:3255S-3261S.
  • [71]Vaidyanathan J, Walle T: Glucuronidation and sulfation of the tea flavonoid (-) epicatechin by the human and rat enzymes. Drug Metab Dispos 2002, 30:897-903.
  • [72]van der Sluis A, Dekker M, de Jager A, Jongen W: Activity and concentration of polyphenolic antioxidants in apple: effect of cultivar, harvest year, and storage conditions. J Agri Food Chem 2001, 49:3606-3613.
  • [73]Hammerstone J, Lazarus S, Schmitz H: Procyanidin content and variation in some commonly consumed foods. J Nutr 2000, 130:2086S-2092S.
  • [74]Awad M, de Jager A, van der Plas L, van der Krol A: Flavonoid and chlorogenic acid changes in skin of Elstar and Jonagold apples during development and ripening. Scientia Hort 2001, 90:69-83.
  • [75]Awad M, Wagenmakers P, de Jager A: Effects of light on flavonoid and chlorogenic acid levels in the skin of Jonagold apples. Scientia Hort. 2001, 88:289-298.
  • [76]Awad M, de Jager A, Westing L: Flavonoid and chlorogenic acid levels in apple fruit: characterisation of variation. Scientia Hort 2000, 83:249-263.
  • [77]Awad M, de Jager A: Relationships between fruit nutrients and concentrations of flavonoids and chlorogenic acid in Elstar apple skin. Scientia Hort 2002, 92:265-276.
  • [78]Awad M, de Jager A: Formation of flavonoids, especially anthocyanin and chlorogenic acid in Jonagold apple skin: influences of growth regulators and fruit maturity. Scientia Hort 2002, 93:257-266.
  • [79]Goulding J, McGlasson B, Wyllie S, Leach D: Fate of apple phenolics during cold storage. J Agri Food Chem 2001, 49:2283-2289.
  • [80]Lattanzio V, Di Vinere D, Linsalata V, Bertolini P, Ippolito A, Salerno M: Low temperature metabolism of apple phenolics and quiescence of Phlyctaena vagabunda. J Agric Food Chem 2001, 49:5817-5821.
  • [81]van der Sluis A, Dekker M, Skrede G, Jongen W: Activity and concentration of polyphenolic antioxidants in apple juice. 1. effect of existing production methods. J Agric Food Chem 2002, 50:7211-7219.
  • [82]Guyot S, Marnet N, Sanoner P, Drilleau J: Variability of the polyphenolic composition of cider apple (Malus domestica) fruits and juices. J Agric Food Chem 2003, 51:6240-6247.
  • [83]Renard C, Baron A, Guyot S, Drilleau J: Interactions between apple cell walls and native apple polyphenols' quantification and some consequences. Int J Biol Macromol 2001, 29:115-125.
  • [84]Lu Y, Foo L: Antioxidant and radical scavenging activities of polyphenols from apple pomace. Food Chem 2000, 68:81-85.
  • [85]Wolfe K, Liu RH: Apple peels as a value-added food ingredient. J Agric Food Chem 2003, 51:1676-1683.
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