Coffee consumption and prostate cancer risk: further evidence for inverse relationship

Nutrition Journal

David S Morrison²  Carole Hart³  Hing Leung¹  Khaver Qureshi⁴  Philip McLoone²  Kashif Shafique³ 

[1] Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK;West of Scotland Cancer Surveillance Unit, University of Glasgow, 1 Lilybank Gardens, Glasgow, G12 8RZ, UK;Institute of Health & Wellbeing, College of Medical, Veterinary and Life Sciences, Public Health, University of Glasgow, 1 Lilybank Gardens, Glasgow, G12 8RZ, UK;Urology Department, Gartnavel General Hospital, 1053 Great Western Road, Glasgow, G12 0YN, UK

关键词: Risk factor;    Gleason grade;    Incidence;    Prostate cancer;    Coffee;   

Others  :  824267
DOI  :  10.1186/1475-2891-11-42

 received in 2012-02-23, accepted in 2012-06-13,  发布年份 2012

【 摘 要 】

Background

Higher consumption of coffee intake has recently been linked with reduced risk of aggressive prostate cancer (PC) incidence, although meta-analysis of other studies that examine the association between coffee consumption and overall PC risk remains inconclusive. Only one recent study investigated the association between coffee intake and grade-specific incidence of PC, further evidence is required to understand the aetiology of aggressive PCs. Therefore, we conducted a prospective study to examine the relationship between coffee intake and overall as well as grade-specific PC risk.

Methods

We conducted a prospective cohort study of 6017 men who were enrolled in the Collaborative cohort study in the UK between 1970 and 1973 and followed up to 31st December 2007. Cox Proportional Hazards Models were used to evaluate the association between coffee consumption and overall, as well as Gleason grade-specific, PC incidence.

Results

Higher coffee consumption was inversely associated with risk of high grade but not with overall risk of PC. Men consuming 3 or more cups of coffee per day experienced 55% lower risk of high Gleason grade disease compared with non-coffee drinkers in analysis adjusted for age and social class (HR 0.45, 95% CI 0.23-0.90, p value for trend 0.01). This association changed a little after additional adjustment for Body Mass Index, smoking, cholesterol level, systolic blood pressure, tea intake and alcohol consumption.

Conclusion

Coffee consumption reduces the risk of aggressive PC but not the overall risk.

【 授权许可】

   
2012 Shafique et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Spiller MA: The chemical components of coffee. Prog Clin Biol Res 1984, 158:91-147.
• [2]Alvarsson M, Hilding A, Ostenson CG: Factors determining normalization of glucose intolerance in middle-aged Swedish men and women: a 8-10-year follow-up. Diabet Med 2009, 26:345-353.
• [3]Huxley R, Lee CM, Barzi F, Timmermeister L, Czernichow S, Perkovic V, et al.: Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysis. Arch Intern Med 2009, 169:2053-2063.
• [4]Tuomilehto J, Hu G, Bidel S, Lindstrom J, Jousilahti P: Coffee consumption and risk of type 2 diabetes mellitus among middle-aged Finnish men and women. JAMA 2004, 291:1213-1219.
• [5]Key TJ: Diet, insulin-like growth factor-1 and cancer risk. Proc Nutr Soc 2011, 70:1-4.
• [6]Hsieh CC, Signorello LB, Lipworth L, Lagiou P, Mantzoros CS, Trichopoulos D: Predictors of sex hormone levels among the elderly: a study in Greece. J Clin Epidemiol 1998, 51:837-841.
• [7]Lagiou P, Signorello LB, Mantzoros CS, Trichopoulos D, Hsieh CC, Trichopoulou A: Hormonal, lifestyle, and dietary factors in relation to leptin among elderly men. Ann Nutr Metab 1999, 43:23-29.
• [8]Albanes D, Weinstein SJ, Wright ME, Mannisto S, Limburg PJ, Snyder K, et al.: Serum insulin, glucose, indices of insulin resistance, and risk of prostate cancer. J Natl Cancer Inst 2009, 101:1272-1279.
• [9]Hsing AW, Gao YT, Chua S, Deng J, Stanczyk FZ: Insulin resistance and prostate cancer risk. J Natl Cancer Inst 2003, 95:67-71.
• [10]Roddam AW, Allen NE, Appleby P, Key TJ, Ferrucci L, Carter HB, et al.: Insulin-like growth factors, their binding proteins, and prostate cancer risk: analysis of individual patient data from 12 prospective studies. Ann Intern Med 2008, 149:461-468.
• [11]Stocks T, Lukanova A, Rinaldi S, Biessy C, Dossus L, Lindahl B, et al.: Insulin resistance is inversely related to prostate cancer: a prospective study in Northern Sweden. Int J Cancer 2007, 120:2678-2686.
• [12]Park CH, Myung SK, Kim TY, Seo HG, Jeon YJ, Kim Y, et al.: Coffee consumption and risk of prostate cancer: a meta-analysis of epidemiological studies. BJU Int 2010, 106:762-769.
• [13]Yu X, Bao Z, Zou J, Dong J: Coffee consumption and risk of cancers: a meta-analysis of cohort studies. BMC Cancer 2011, 11:96. BioMed Central Full Text
• [14]Gallus S, Foschi R, Talamini R, Altieri A, Negri E, Franceschi S, et al.: Risk factors for prostate cancer in men aged less than 60 years: a case–control study from Italy. Urology 2007, 70:1121-1126.
• [15]Opalinska E, Michalak A, Stoma F, Latalski M, Goniewicz M: Increasing level of prostate-specific antigen and prostate cancer risk factors among 193 men examined in screening procedure. Ann Univ Mariae Curie Sklodowska Med 2003, 58:57-63.
• [16]Hsieh CC, Thanos A, Mitropoulos D, Deliveliotis C, Mantzoros CS, Trichopoulos D: Risk factors for prostate cancer: a case–control study in Greece. Int J Cancer 1999, 80:699-703.
• [17]Jain MG, Hislop GT, Howe GR, Burch JD, Ghadirian P: Alcohol and other beverage use and prostate cancer risk among Canadian men. Int J Cancer 1998, 78:707-711.
• [18]Sharpe CR, Siemiatycki J: Consumption of non-alcoholic beverages and prostate cancer risk. Eur J Cancer Prev 2002, 11:497-501.
• [19]Slattery ML, West DW: Smoking, alcohol, coffee, tea, caffeine, and theobromine: risk of prostate cancer in Utah (United States). Cancer Causes Control 1993, 4:559-563.
• [20]Wilson KM, Kasperzyk JL, Rider JR, Kenfield S, van Dam RM, Stampfer MJ, et al.: Coffee consumption and prostate cancer risk and progression in the health professionals follow-up study. J Natl Cancer Inst 2011, 103:876-884.
• [21]Hart CL, MacKinnon PL, Watt GC, Upton MN, McConnachie A, Hole DJ, et al.: The Midspan studies. Int J Epidemiol 2005, 34:28-34.
• [22]Davey Smith G, Hart C, Hole D, MacKinnon P, Gillis C, Watt G, et al.: Education and occupational social class: which is the more important indicator of mortality risk? Journal Epidemiol Community Health 1998, 52:153-160.
• [23]Hart CL, Davey Smith G, Hole DJ, Hawthorne VM: Alcohol consumption and mortality from all causes, coronary heart disease, and stroke: results from a prospective cohort study of Scottish men with 21 years of follow up. Br Med Journal 1999, 318:1725-1729.
• [24]Classification of Occupations. HMSO, London; 1966:1-136.
• [25]Hart CL, Batty GD, Morrison DS, Mitchell RJ, Davey Smith G: Obesity, overweight and liver disease in the Midspan prospective cohort studies. Int J Obesity 2010, 34:1051-1059.
• [26]Simmons MN, Berglund RK, Jones JS: A practical guide to prostate cancer diagnosis and management. Cleve Clin J Med 2011, 78:321-331.
• [27]Mucci LA, Tamimi R, Lagiou P, Trichopoulou A, Benetou V, Spanos E, et al.: Are dietary influences on the risk of prostate cancer mediated through the insulin-like growth factor system? BJU Int 2001, 87:814-820.
• [28]Cardenas C, Quesada AR, Medina MA: Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene. PLoS One 2011, 6:e23407.
• [29]Kempf K, Herder C, Erlund I, Kolb H, Martin S, Carstensen M, et al.: Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial. Am J Clin Nutr 2010, 91:950-957.
• [30]Maitland NJ, Collins AT: Inflammation as the primary aetiological agent of human prostate cancer: a stem cell connection? J Cel Biochem 2008, 105:931-939.
• [31]Key TJ, Appleby PN, Allen NE, Travis RC, Roddam AW, Jenab M, et al.: Plasma carotenoids, retinol, and tocopherols and the risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition study. Am J Clin Nutr 2007, 86:672-681.
• [32]Park Y, Mitrou PN, Kipnis V, Hollenbeck A, Schatzkin A, Leitzmann MF: Calcium, dairy foods, and risk of incident and fatal prostate cancer: the NIH-AARP Diet and Health Study. Am J Epidemiol 2007, 166:1270-1279.
• [33]Rodriguez C, McCullough ML, Mondul AM, Jacobs EJ, Chao A, Patel AV, et al.: Meat consumption among Black and White men and risk of prostate cancer in the Cancer Prevention Study II Nutrition Cohort. Cancer Epidemiol Biomarkers Prev 2006, 15:211-216.