Cranial radiotherapy predisposes to abdominal adiposity in survivors of childhood acute lymphocytic leukemia

Radiation Oncology

Gil Guerra-Junior¹  Henrique Lederman³  Bruno Geloneze⁵  Solange Andreoni²  Maria Lúcia de Martino Lee⁴  Angela Maria Spinola-Castro⁶  Adriana Aparecida Siviero-Miachon⁶ 

[1] UNICAMP, Faculty of Medical Sciences, Department of Pediatrics, Division of Pediatric Endocrinology, State University of Campinas, Campinas, Brazil;UNIFESP/EPM, Department of Preventive and Social Medicine, Division of Biostatistics, Federal University of Sao Paulo, Sao Paulo, Brazil;UNIFESP/EPM, Department of Diagnostic Imaging, Federal University of Sao Paulo, Sao Paulo, Brazil;Pediatric Oncology Institute - IOP/GRAACC, Sao Paulo, Brazil;UNICAMP, Faculty of Medical Sciences, Laboratory of Investigation on Metabolism and Diabetes - LIMED, State University of Campinas, Campinas, Brazil;UNIFESP/EPM, Department of Pediatrics, Division of Pediatric Endocrinology, Federal University of Sao Paulo, Sao Paulo, Brazil

关键词: Insulin resistance;    Lipid metabolism disorders;    Abdominal fat;    Adiposity;    Precursor cell lymphoblastic leukemia-lymphoma/radiotherapy;   

Others  :  1154554
DOI  :  10.1186/1748-717X-8-39

 received in 2012-07-17, accepted in 2013-02-11,  发布年份 2013

【 摘 要 】

Background

Advances in treatment of acute lymphocytic leukemia increased the likelihood of developing late treatment-associated effects, such as abdominal adiposity, increasing the risk of cardiovascular disease in this population. Cranial radiotherapy is one of the factors that might be involved in this process. The aim of this study was to determine the effect of cranial radiotherapy on adiposity indexes in survivors of acute lymphocytic leukemia.

Methods

A comparative cross-sectional study of 56 acute lymphocytic leukemia survivors, chronological age between 15 and 24 years, assigned into two groups according to the exposure to cranial radiotherapy (25 irradiated and 31 non-irradiated), assessed according to body fat (dual energy X-ray absorptiometry), computed tomography scan-derived abdominal adipose tissue, lipid profile, and insulin resistance.

Results

Cranial radiotherapy increased body fat and abdominal adipose tissue and altered lipid panel. Yet, lipids showed no clinical relevance so far. There were significantly more obese patients among those who received cranial radiotherapy (52% irradiated versus 22.6% non-irradiated), based on dual energy X-ray absorptiometry body fat measurements. Nonetheless, no association was observed between cranial radiotherapy and body mass index, waist circumference, waist-to-height ratio or insulin resistance.

Conclusions

Adolescent and young adult survivors of childhood acute lymphocytic leukemia showed an increase in body fat and an alteration of fat distribution, which were related to cranial radiotherapy. Fat compartment modifications possibly indicate a disease of adipose tissue, and cranial radiotherapy imports in this process.

【 授权许可】

   
2013 Siviero-Miachon et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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