Interobserver variability in the delineation of the tumour bed using seroma and surgical clips based on 4DCT scan for external-beam partial breast irradiation

Radiation Oncology

Yanluan Guo²  Chaoqian Liang¹  Yingjie Zhang¹  Qian Shao¹  Min Xu¹  Wei Wang¹  Jianbin Li¹  Bing Guo² 

[1] Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jiyan Road, Jinan 250117, Shandong Province, China;Medicine and Life Sciences College of Shandong Academy of Medical Sciences, Jinan University, Jinan, Shandong Province, People’s Republic of China

关键词: Seroma;    Surgical clips;    Interobserver variability;    Four-dimensional computed tomography;    Breast cancer;   

Others  :  1139640
DOI  :  10.1186/s13014-015-0370-3

 received in 2014-10-14, accepted in 2015-02-25,  发布年份 2015

【 摘 要 】

Background

To explore the interobserver variability in the delineation of the tumour bed using seroma and surgical clips based on the four-dimensional computed tomography (4DCT) scan for external-beam partial breast irradiation (EB-PBI) during free breathing.

Methods

Patients with a seroma clarity score (SCS) 3 ~ 5 and ≥5 surgical clips in the lumpectomy cavity after breast-conserving surgery who were recruited for EB-PBI underwent 4DCT simulation. Based on the ten sets of 4DCT images acquired, the tumour bed formed using the clips, the seroma, and both the clips and seroma (defined as TB_C, TB_S and TB_C+S, respectively) were delineated by five radiation oncologists using specific guidelines. The following parameters were calculated to analyse interobserver variability: volume of the tumour bed (TB_C, TB_S, TB_C+S), coefficient of variation (COV_C, COV_S, COV_C+S), and matching degree (MD_C, MD_S, MD_C+S).

Results

The interobserver variability for TB_C and TB_C+S and for COV_C and COV_C+S were statistically significant (p = 0.021, 0.008, 0.002, 0.015). No significant difference was observed for TB_S and COV_S (p = 0.867, 0.061). Significant differences in interobserver variability were observed for MD_C vs MD_S, MD_C vs MD_C+S, MD_S vs MD_C+S (p = 0.000, 0.032, 0.008), the interobserver variability of MD_S was smaller than that of MD_C and MD_C+S (MD_S > MD_C+S > MD_C).

Conclusions

When the SCS was 3 ~ 5 points and the number of surgical clips was ≥5, interobserver variability was minimal for the delineation of the tumour bed based on seroma.

【 授权许可】

   
2015 Guo et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

Figure 2.

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