Seroepidemiology of infection with Toxoplasma gondii in migrant agricultural workers living in poverty in Durango, Mexico

Particle and Fibre Toxicology

Oliver Liesenfeld²  Federico Campillo-Ruiz³  Cosme Alvarado-Esquivel¹ 

[1] Laboratorio de Investigación Biomédica, Facultad de Medicina y Nutrición, Universidad Juárez del Estado de Durango. Avenida Universidad S/N, Durango, Dgo 34000, México;Present address: Roche Molecular Diagnostics, Pleasanton, CA, USA;Servicios de Salud de Durango. Independencia y Puebla S/N, Canatlán, Durango 34450, México

关键词: Cross-sectional study;    Migrant workers;    Seroprevalence;    Toxoplasma gondii;   

Others  :  1227989
DOI  :  10.1186/1756-3305-6-113

 received in 2013-03-05, accepted in 2013-04-17,  发布年份 2013

【 摘 要 】

Background

Migrant agricultural workers are a group of people living in poverty with poor housing, sanitary conditions and hygiene practices. Little is known about the epidemiology of infection with Toxoplasma gondii in migrant agricultural workers.

Methods

We investigated the presence of anti-Toxoplasma IgG and IgM antibodies in 173 migrant workers hired for seasonal agricultural work in Durango State in northern Mexico using enzyme-linked immunoassays.

Results

Of the 173 migrant workers (mean age 34.82 ± 14.01 years), 50 (28.9%) had anti-Toxoplasma IgG antibodies and 36 (20.8%) had anti-Toxoplasma IgM antibodies. Seroprevalence was not influenced by gender, age, birth place, or educational level. In contrast, seroprevalence was significantly higher in workers residing in rural areas than those in urban or suburban areas. Migrant workers suffering from memory impairment, dizziness, or syncope had significantly higher seroprevalence of anti-T. gondii IgG antibodies than those without such clinical features. Logistic regression analysis showed that T. gondii exposure was positively associated with consumption of unwashed raw vegetables (OR = 2.39; 95% CI: 1.06-5.35; P = 0.03) and low frequency of eating out of home (OR = 3.87; 95% CI: 1.43-10.42; P = 0.007), and negatively associated with national trips (OR = 0.30; 95% CI: 0.13-0.65; P = 0.003) and consumption of raw milk (OR = 0.40; 95% CI: 0.18-0.87; P = 0.02). Other behavioral characteristics including consumption of meat or untreated water were not associated with T. gondii infection.

Conclusions

This is the first report of T. gondii infection in internal migrant agricultural workers living in poverty. Results deserve further investigation of causal relations between clinical symptoms and infection, and may be useful for optimal planning of preventive measures.

【 授权许可】

   
2013 Alvarado-Esquivel et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Dubey JP: Toxoplasmosis of animals and humans. Boca Raton, Florida: Second Edition. CRC Press; 2010.
• [2]Montoya JG, Liesenfeld O: Toxoplasmosis. Lancet 2004, 363:1965-1976.
• [3]Walker M, Zunt JR: Parasitic central nervous system infections in immunocompromised hosts. Clin Infect Dis 2005, 40:1005-1015.
• [4]Balasundaram MB, Andavar R, Palaniswamy M, Venkatapathy N: Outbreak of acquired ocular toxoplasmosis involving 248 patients. Arch Ophthalmol 2010, 128:28-32.
• [5]Jackson MH, Hutchison WM, Siim JC: A seroepidemiological survey of toxoplasmosis in Scotland and England. Ann Trop Med Parasitol 1987, 81:359-365.
• [6]Bartolomé Alvarez J, Martínez Serrano M, Moreno Parrado L, Lorente Ortuño S, Crespo Sánchez MD: Prevalence and incidence in Albacete, Spain, of Toxoplasma gondii infection in women of childbearing age: differences between immigrant and non-immigrant (2001–2007). Rev Esp Salud Publica 2008, 82:333-342.
• [7]Chan BT, Amal RN, Hayati MI: Seroprevalence of toxoplasmosis among migrant workers from different Asian countries working in Malaysia. Southeast Asian J Trop Med Public Health 2008, 39:9-13.
• [8]Alvarado-Esquivel C, Cruz-Magallanes HM, Esquivel-Cruz R, Estrada-Martínez S, Rivas-González M, Liesenfeld O, Martínez-García SA, Ramírez E, Torres-Castorena A, Castañeda A, Dubey JP: Seroepidemiology of Toxoplasma gondii infection in human adults from three rural communities in Durango State, Mexico. J Parasitol 2008, 94:811-816.
• [9]Alvarado-Esquivel C, Rojas-Rivera A, Estrada-Martínez S, Sifuentes-Álvarez A, Liesenfeld O, García-López CR, Dubey JP: Seroepidemiology of Toxoplasma gondii infection in a Mennonite community in Durango State, Mexico. J Parasitol 2010, 96:941-945.
• [10]Alvarado-Esquivel C, Estrada-Martínez S, Pizarro-Villalobos H, Arce-Quiñones M, Liesenfeld O, Dubey JP: Seroepidemiology of Toxoplasma gondii infection in general population in a northern Mexican City. J Parasitol 2011, 97:40-43.
• [11]Alvarado-Esquivel C, Estrada-Martínez S: Toxoplasma gondii infection and abdominal hernia: evidence of a new association. Parasit Vectors 2011, 4:112. BioMed Central Full Text
• [12]Alvarado-Esquivel C, Torres-Berumen JL, Estrada-Martínez S, Liesenfeld O, Mercado-Suarez MF: Toxoplasma gondii infection and liver disease: a case–control study in a northern Mexican population. Parasit Vectors 2011, 4:75. BioMed Central Full Text
• [13]Alvarado-Esquivel C, Estrada-Martínez S, García-López CR, Rojas-Rivera A, Sifuentes-Álvarez A, Liesenfeld O: Seroepidemiology of Toxoplasma gondii infection in Tepehuanos in Durango, Mexico. Vector Borne Zoonotic Dis 2012, 12:138-142.
• [14]Alvarado-Esquivel C, Sifuentes-Álvarez A, Narro-Duarte SG, Estrada-Martínez S, Díaz-García JH, Liesenfeld O, Martínez-García SA, Canales-Molina A: Seroepidemiology of Toxoplasma gondii infection in pregnant women in a public hospital in northern Mexico. BMC Infect Dis 2006, 6:113. BioMed Central Full Text
• [15]Alvarado-Esquivel C, Mercado-Suárez MF, Rodriguez-Briones A, Fallad-Torres L, Ayala-Ayala JO, Nevarez-Piedra LJ, Duran-Morales E, Estrada-Martínez S, Liesenfeld O, Márquez-Conde JA, Martínez-García SA: Seroepidemiology of infection with Toxoplasma gondii in healthy blood donors of Durango. Mexico. BMC Infect Dis 2007, 7:75. BioMed Central Full Text
• [16]Alvarado-Esquivel C, Liesenfeld O, Torres-Castorena A, Estrada-Martínez S, Urbina-Álvarez JD, Ramos-de la Rocha M, Márquez-Conde JA, Dubey JP: Seroepidemiology of Toxoplasma gondii infection in patients with vision and hearing impairments, cancer, HIV, or undergoing hemodialysis in Durango, Mexico. J Parasitol 2010, 96:505-508.
• [17]Velasco-Castrejón O, Salvatierra-Izaba B, Valdespino JL, Sedano-Lara AM, Galindo-Virgen S, Magos C, Llausás A, Tapia-Conyer R, Gutiérrez G, Sepúlveda J: Seroepidemiology of toxoplasmosis in Mexico. Salud Publica Mex 1992, 34:222-229.
• [18]Galvan-Ramirez Mde L, Troyo R, Roman S, Calvillo-Sanchez C, Bernal-Redondo R: A systematic review and meta-analysis of Toxoplasma gondii infection among the Mexican population. Parasit Vectors 2012, 5:271. BioMed Central Full Text
• [19]Liesenfeld O, Press C, Montoya JG: False-positive results in immunoglobulin M (IgM) Toxoplasma antibody tests and importance of confirmatory testing: the Platelia Toxo IgM test. J Clin Microbiol 1997, 35:174-178.
• [20]Uneke CJ, Duhlinska DD, Njoku MO, Ngwu BA: Seroprevalence of acquired toxoplasmosis in HIV-infected and apparently healthy individuals in Jos, Nigeria. Parassitologia 2005, 47:233-236.
• [21]Prandota J: Recurrent headache as the main symptom of acquired cerebral toxoplasmosis in nonhuman immunodeficiency virus-infected subjects with no lymphadenopathy: the parasite may be responsible for the neurogenic inflammation postulated as a cause of different types of headaches. Am J Ther 2007, 14:63-105.
• [22]Silva CS, Neves Ede S, Benchimol EI, Moraes DR: Postnatal acquired toxoplasmosis patients in an infectious diseases reference center. Braz J Infect Dis 2008, 12:438-441.
• [23]Alvarado-Esquivel C, Liesenfeld O, Márquez-Conde JA, Estrada-Martínez S, Dubey JP: Seroepidemiology of infection with Toxoplasma gondii in workers occupationally exposed to water, sewage, and soil in Durango, Mexico. J Parasitol 2010, 96:847-850.
• [24]Alvarado-Esquivel C, Estrada-Martínez S, Liesenfeld O: Toxoplasma gondii infection in workers occupationally exposed to unwashed raw fruits and vegetables: a case control seroprevalence study. Parasit Vectors 2011, 4:235. BioMed Central Full Text
• [25]Alvarado-Esquivel C, Torres-Castorena A, Liesenfeld O, Estrada-Martínez S, Urbina-Álvarez JD: High seroprevalence of Toxoplasma gondii infection in a subset of Mexican patients with work accidents and low socioeconomic status. Parasit Vectors 2012, 5:13. BioMed Central Full Text