Impact of exacerbations of cystic fibrosis on muscle strength

Respiratory Research

Thierry Troosters²  Lieven Dupont¹  Marc Decramer²  Rik Gosselink²  Kristine Colpaert¹  Daniel Langer²  Bart Vrijsen¹  Hans Van Remoortel²  Chris Burtin² 

[1] Adult Cystic Fibrosis Centre, University Hospitals KULeuven, Leuven, Belgium;Respiratory Rehabilitation and Respiratory Division, University Hospitals KU Leuven, Herestraat 49 bus 706, Leuven, B3000, Belgium

关键词: Quadriceps strength;    Magnetic stimulation;    Hospitalization;    Exacerbation;    Cystic fibrosis;    Physical activity;    Muscle function;   

Others  :  794730
DOI  :  10.1186/1465-9921-14-46

 received in 2012-11-08, accepted in 2013-04-10,  发布年份 2013

【 摘 要 】

Background

Adult patients with cystic fibrosis have peripheral muscle weakness, which is related to exercise intolerance and poor prognosis. The influence of acute exacerbations on muscle strength has been poorly studied. This study aimed to investigate whether quadriceps force (QF), as assessed with an involuntary technique, changes during intravenous antibiotics therapy (IVAT) for an exacerbation.

Methods

QF was measured in 20 patients using twitch stimulation of the femoral nerve at the day of hospitalization (day 1) and at termination (day 14) of the IVAT. Physical activity was monitored during IVAT using a SenseWear armband. Ten stable patients served as control subjects.

Results

QF did not change during exacerbation (potentiated twitch force at day 1: 140 ± 42 N, at day 14: 140 ± 47 N), but a decrease was observed in individual patients. Changes in twitch force during exacerbation were correlated with time spent in activities of at least moderate intensity (r = 0.61, p = 0.007).

Conclusions

QF does not systematically decrease during exacerbations of cystic fibrosis. Individual changes in QF are well correlated with daily time spent in activities of at least moderate intensity.

【 授权许可】

   
2013 Burtin et al.; licensee BioMed Central Ltd.

【 图 表 】

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