Striking life events associated with primary breast cancer susceptibility in women: a meta-analysis study

Journal of Experimental & Clinical Cancer Research

Qiang Sun¹  Ke Wang²  Guangliang Shan²  Li Peng¹  Xin Huang¹  Ying Zhong¹  Changjun Wang¹  Yan Lin¹ 

[1] Department of Breast Disease, Peking Union Medical College Hospital, Peking Union Medical College, 1 Shuaifuyuan, Wangfujing, Beijing 100730, China;Department of Epidemiology, Insititue of Basic Medical Sciences, Peking Union Medical College, Beijing 100730, China

关键词: Risk;    Severe life events;    Striking life events;    Breast cancer;   

Others  :  824781
DOI  :  10.1186/1756-9966-32-53

 received in 2013-07-01, accepted in 2013-08-10,  发布年份 2013

【 摘 要 】

Purpose

The association between striking life events, an important stress and acute anxiety disorder, and the occurrence of primary breast cancer is unclear. The current meta-analysis was designed to assess the relationship between striking life events and primary breast cancer incidence in women.

Methods

Systematic computerized searching of the PubMed, ScienceDirect, Embase, and BMJ databases with the combinations of controlled descriptors from Mesh, including breast cancer, breast tumor, cancer of breast, mammary carcinoma, life events, lifechange events, case–control studies, case-base studies, cohort study, and cohort analysis and identified a total of 307 papers published from January 1995 to April 2012. Following evaluation of methodological quality with the Downs & Black criteria, seven case–control or cohort studies were selected and the association between striking life events and primary breast cancer incidence in women was measured using random effect or fixed-effect odds ratios combined with 95% confidence interval.

Results

The seven studies included in the final meta-analysis included 99,807 women. A meta-analysis showed that the pooled OR for striking life events and breast cancer was 1.51 (95% CI 1.15 - 1.97, P = 0.003), indicating that women with striking life events were at 1.5-fold greater risk of developing breast cancer. The pooled OR for severe striking life events and breast cancer was 2.07 (95% CI 1.06 - 4.03), indicating that women with severe striking life events were at 2-fold greater risk of developing breast cancer.

Conclusions

The current meta-analysis showed significant evidence for a positive association between striking life events and primary breast cancer incidence in women.

【 授权许可】

   
2013 Lin et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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