Necrotizing sarcoid granulomatosis with hemoptysis: a case report and literature review

Diagnostic Pathology

Michael Simoff⁸  Wolfgang Hohenforst-Schmidt⁴  Andreas Gschwendtner¹  Konstantinos Zarogoulidis⁶  Paul Zarogoulidis⁵  Zhi Zhu⁷  Weiqiang Zheng⁷  Qiang Li²  Chong Bai²  Chen Li³  Haidong Huang² 

[1] Pathology Department, Hospital of Amberg, Amberg, Germany;Department of Respiratory Diseases, Changhai Hospital, Second Military Medical University, Shanghai, China;Department of respiration, First Automobile Works General Hospital/ fourth Affiliated Hospital of Jilin University, Shanghai, China;II Medical Clinic, ``Coburg`` Hospital, University of Wuerzburg, Coburg, Germany;Department of Interventional Pneumology, Ruhrlandklinik, West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany;Pulmonary Department, G. Papanikolaou`` General Hopspital, Aristotle University of Thessaloniki, Thessaloniki, Greece;Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China;Bronchoscopy and Interventional Pulmonology, Pulmonary and Critical Care Medicine, Henry Ford Hospital, Detroit, MI, USA

关键词: Hemoptysis;    Bronchoscopy;    Necrosis;    Vasculitis;    Granuloma;    Necrotizing sarcoid granulomatosis;   

Others  :  806985
DOI  :  10.1186/1746-1596-8-79

 received in 2013-03-05, accepted in 2013-05-09,  发布年份 2013

【 摘 要 】

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We present a case of 39-year-old male with the symptoms of fever, cough, chest pain and bloody phlegm, whose chest CT showed multiple subpleural nodules and inflammatory infiltration. Video-Assisted Thoracic Surgery ( VATS ) for right subplural nodule was performed and confirmed the diagnosis of necrotizing sarcoid granulomatosis. Prednisolone was administered and the symptoms were under control untill the occurrence of intermittent hemoptysis after 10 months. Chest CT and bronchoscope revealed the right lower lobe nodule with intraluminal necrotic tissue in the right lower lobe posterior basal segment respectively. Fatal hemoptysis happened during endobronchial biopsy by flexible bronchoscope forcep. Based on this case, we reviewed the relevant literature and discussed the clinical features, pathological changes and prognosis of the disease.

【 授权许可】

   
2013 Huang et al.; licensee BioMed Central Ltd.

【 图 表 】

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