A prospective cross-sectional study on quality of life and treatment satisfaction in type 2 diabetic patients with retinopathy without other major late diabetic complications

Health and Quality of Life Outcomes

Didac Mauricio⁴  Carmen Jurjo²  Marta Hernandez⁵  Montserrat Martinez-Alonso³  Alicia Traveset²  Esther Rubinat⁵  Nuria Alcubierre¹ 

[1] Institut de Recerca Biomèdica de Lleida, University of Lleida, Lleida, Spain;Department of Ophthalmology, University Hospital Arnau de Vilanova, Lleida, Spain;Biostatistics Unit, Institut de Recerca Biomèdica de Lleida, University of Lleida, Lleida, Spain;Department of Endocrinology and Nutrition, Hospital Germans Trias Pujol, Carretera Canyet, S/N, Badalona, 08916, Spain;Department of Endocrinology and Nutrition, University Hospital Arnau de Vilanova, Lleida, Spain

关键词: Type 2 diabetes mellitus;    Specific questionnaires;    Treatment satisfaction;    Quality of life;    Diabetic retinopathy;   

Others  :  1164537
DOI  :  10.1186/s12955-014-0131-2

 received in 2014-04-14, accepted in 2014-08-12,  发布年份 2014

【 摘 要 】

Background

To assess quality of life and treatment satisfaction in patients with type 2 diabetes mellitus with diabetic retinopathy (DR) using validated instruments, with comparison to patients without DR.

Methods

A prospective cross-sectional study was designed to assess the influence of retinopathy on quality of life and treatment satisfaction in patients with type 2 diabetes mellitus who do not have any other advanced late complications that could interfere with these outcomes. We included 148 patients with DR and 149 without DR, all without other advanced diabetic complications. Quality of life was assessed using the Audit of Diabetes Dependent Quality of Life (ADDQoL) questionnaire, and treatment satisfaction was assessed using the Diabetes Treatment Satisfaction Questionnaire (DTSQ). Clinical and treatment variables related to diabetes were also collected. The degree of DR was classified according to the International Clinical Classification System. Multivariate linear regression models were used to model the ADDQoL and DTSQ scores according to sociodemographical and clinical characteristics, and to model the adjusted relationship of DTSQ with ADDQoL. In DR patients, a subanalysis assessed the relationship of these scores with the degree of retinopathy, severity of macular edema, and previous photocoagulation treatment.

Results

DR was associated with significantly lower quality of life (p < 0.001), when examining the two general quality of life items and most of the specific domains. Concerning DTSQ, no difference was found in the total score, and only two domains that assess the perception of glycemic control (hyper- and hypoglycemia) showed a worse score in DR (p < 0.001 and p = 0.008, respectively). Quality of life was significantly affected by the severity of DR, and treatment satisfaction was significantly affected by the severity of macular edema. In the multivariate analysis, a significant effect of the interaction between diabetes duration, insulin therapy, and the presence of DR was found for both, ADDQoL and DTSQ.

Conclusion

In the absence of other major complications, DR has a negative impact on quality of life in patients with type 2 diabetes. Further, treatment satisfaction was not affected by the presence of DR.

【 授权许可】

   
2014 Alcubierre et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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