Journal of Neuroinflammation | |
Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons | |
Consuelo Amantini2  Massimo Nabissi1  Matteo Santoni4  Maria Beatrice Morelli3  Claudio Cardinali3  Giorgio Santoni1  | |
[1] School of Pharmacy, Section of Experimental Medicine, University of Camerino, Camerino 62032, Italy;School of Biosciences and Veterinary Medicine, University of Camerino, Camerino 62032, Italy;Department of Molecular Medicine, Sapienza University, Rome 00185, Italy;Department of Medical Oncology, AOU Ospedali Riuniti, Polytechnic University of Marche, Ancona 60126, Italy | |
关键词: TRP channels; Ion channels; TLRs; PRRs; DAMPs; PAMPs; Caspase-1; IL-1β; Inflammasome; Innate immunity; | |
Others : 1149675 DOI : 10.1186/s12974-015-0239-2 |
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received in 2014-07-25, accepted in 2015-01-07, 发布年份 2015 | |
【 摘 要 】
An increasing number of studies show that the activation of the innate immune system and inflammatory mechanisms play an important role in the pathogenesis of numerous diseases. The innate immune system is present in almost all multicellular organisms and its activation occurs in response to pathogens or tissue injury via pattern-recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs). Intracellular pathways, linking immune and inflammatory response to ion channel expression and function, have been recently identified. Among ion channels, the transient receptor potential (TRP) channels are a major family of non-selective cation-permeable channels that function as polymodal cellular sensors involved in many physiological and pathological processes.
In this review, we summarize current knowledge of interactions between immune cells and PRRs and ion channels of TRP families with PAMPs and DAMPs to provide new insights into the pathogenesis of inflammatory diseases. TRP channels have been found to interfere with innate immunity via both nuclear factor-kB and procaspase-1 activation to generate the mature caspase-1 that cleaves pro-interleukin-1β cytokine into the mature interleukin-1β.
Sensory neurons are also adapted to recognize dangers by virtue of their sensitivity to intense mechanical, thermal and irritant chemical stimuli. As immune cells, they possess many of the same molecular recognition pathways for danger. Thus, they express PRRs including Toll-like receptors 3, 4, 7, and 9, and stimulation by Toll-like receptor ligands leads to induction of inward currents and sensitization in TRPs. In addition, the expression of inflammasomes in neurons and the involvement of TRPs in central nervous system diseases strongly support a role of TRPs in inflammasome-mediated neurodegenerative pathologies. This field is still at its beginning and further studies may be required.
Overall, these studies highlight the therapeutic potential of targeting the inflammasomes in proinflammatory, autoinflammatory and metabolic disorders associated with undesirable activation of the inflammasome by using specific TRP antagonists, anti-human TRP monoclonal antibody or different molecules able to abrogate the TRP channel-mediated inflammatory signals.
【 授权许可】
2015 Santoni et al.; licensee BioMed Central.
【 预 览 】
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