Uncovering the link between malfunctions in Drosophila neuroblast asymmetric cell division and tumorigenesis

Cell & Bioscience

Wange Lu¹  Corey Kelsom¹ 

[1] Department of Biochemistry and Molecular Biology, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, 1425 San Pablo Street, Los Angeles, CA, 90033, USA

关键词: Tumorigenesis;    Spindle orientation;    Determinants;    Polarity;    Neuroblasts;    Asymmetric cell division;   

Others  :  793113
DOI  :  10.1186/2045-3701-2-38

 received in 2012-09-02, accepted in 2012-11-05,  发布年份 2012

【 摘 要 】

Asymmetric cell division is a developmental process utilized by several organisms. On the most basic level, an asymmetric division produces two daughter cells, each possessing a different identity or fate. Drosophila melanogaster progenitor cells, referred to as neuroblasts, undergo asymmetric division to produce a daughter neuroblast and another cell known as a ganglion mother cell (GMC). There are several features of asymmetric division in Drosophila that make it a very complex process, and these aspects will be discussed at length. The cell fate determinants that play a role in specifying daughter cell fate, as well as the mechanisms behind setting up cortical polarity within neuroblasts, have proved to be essential to ensuring that neurogenesis occurs properly. The role that mitotic spindle orientation plays in coordinating asymmetric division, as well as how cell cycle regulators influence asymmetric division machinery, will also be addressed. Most significantly, malfunctions during asymmetric cell division have shown to be causally linked with neoplastic growth and tumor formation. Therefore, it is imperative that the developmental repercussions as a result of asymmetric cell division gone awry be understood.

【 授权许可】

   
2012 Kelsom and Lu; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

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