Role of viruses in the development of breast cancer

Infectious Agents and Cancer

Nargis Karatayeva²  Marzhan Sypabekova²  Assel Mussabekova²  Ainur Kakpenova²  Kenneth Alibek¹ 

[1] National Medical Holding, 2 Syganak Street, Astana 010000, Kazakhstan;Nazarbayev University, 53 Kabanbay Batyr Avenue, Astana 010000, Kazakhstan

关键词: Breast cancer;    Infectious agents;    Carcinogenesis;   

Others  :  802774
DOI  :  10.1186/1750-9378-8-32

 received in 2013-02-28, accepted in 2013-08-22,  发布年份 2013

【 摘 要 】

The most common cancer worldwide among women is breast cancer. The initiation, promotion, and progression of this cancer result from both internal and external factors. The International Agency for Research on Cancer stated that 18-20% of cancers are linked to infection, and the list of definite, probable, and possible carcinogenic agents is growing each year. Among them, biological carcinogens play a significant role. In this review, data covering infection-associated breast and lung cancers are discussed and presented as possible involvements as pathogens in cancer. Because carcinogenesis is a multistep process with several contributing factors, we evaluated to what extent infection is significant, and concluded that members of the herpesvirus, polyomavirus, papillomavirus, and retrovirus families definitely associate with breast cancer. Detailed studies of viral mechanisms support this conclusion, but have presented problems with experimental settings. It is apparent that more effort needs to be devoted to assessing the role of these viruses in carcinogenesis, by characterizing additional confounding and synergistic effects of carcinogenic factors. We propose that preventing and treating infections may possibly stop or even eliminate certain types of cancers.

【 授权许可】

   
2013 Alibek et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Cancer facts and figures 2012. http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-031941.pdf webcite
• [2]WHO Cancer. http://www.who.int/mediacentre/factsheets/fs297/en/ webcite
• [3]Parkin DM: The global health burden of infection-associated cancers in the year 2002. International journal of cancer Journal international du cancer 2006, 118(12):3030-3044.
• [4]Aituov B, Duisembekova A, Bulenova A, Alibek K: Pathogen-driven gastrointestinal cancers: Time for a change in treatment paradigm? Infectious agents and cancer 2012, 7(1):18. BioMed Central Full Text
• [5]Alibek K, Kakpenova A, Baiken Y: Role of infectious agents in the carcinogenesis of brain and head and neck cancers. Infectious agents and cancer 2013, 8(1):7. BioMed Central Full Text
• [6]Alibek K, Karatayeva N, Bekniyazov I: The role of infectious agents in urogenital cancers. Infectious agents and cancer 2012, 7(1):35. BioMed Central Full Text
• [7]Mantovani A, Allavena P, Sica A, Balkwill F: Cancer-related inflammation. Nature 2008, 454(7203):436-444.
• [8]de Martel C, Franceschi S: Infections and cancer: established associations and new hypotheses. Critical reviews in oncology/hematology 2009, 70:183-194.
• [9]Porta C, Riboldi E, Sica A: Mechanisms linking pathogens-associated inflammation and cancer. Cancer letters 2011, 305:250-262.
• [10]Aggarwal BB, Shishodia S, Sandur SK, Pandey MK, Sethi G: Inflammation and cancer: how hot is the link? Biochemical pharmacology 2006, 72:1605-1621.
• [11]Lu H, Ouyang W, Huang C: Inflammation, a key event in cancer development. Molecular cancer research : MCR 2006, 4:221-233.
• [12]Amarante MK, Watanabe MA: The possible involvement of virus in breast cancer. J Cancer Res Clin Oncol 2009, 135(3):329-337.
• [13]Khan G, Philip PS, Al Ashari M: Is Epstein-Barr virus associated with aggressive forms of breast cancer? Br J Cancer 2011, 104(8):1362-1363. author reply 1364
• [14]Khan G, Philip PS, Al Ashari M, Houcinat Y, Daoud S: Localization of Epstein-Barr virus to infiltrating lymphocytes in breast carcinomas and not malignant cells. Exp Mol Pathol 2011, 91(1):466-470.
• [15]Mazouni C, Fina F, Romain S, Ouafik L, Bonnier P, Brandone JM, Martin PM: Epstein-Barr virus as a marker of biological aggressiveness in breast cancer. Br J Cancer 2011, 104(2):332-337.
• [16]He JR, Tang LY, Yu DD, Su FX, Song EW, Lin Y, Wang SM, Lai GC, Chen WQ, Ren ZF: Epstein-Barr virus and breast cancer: serological study in a high-incidence area of nasopharyngeal carcinoma. Cancer Lett 2011, 309(2):128-136.
• [17]He JR, Chen LJ, Su Y, Cen YL, Tang LY, Yu DD, Chen WQ, Wang SM, Song EW, Ren ZF: Joint effects of Epstein-Barr virus and polymorphisms in interleukin-10 and interferon-γ on breast cancer risk. J Infect Dis 2012, 205(1):64-71.
• [18]Huo Q, Zhang N, Yang Q: Epstein-Barr virus infection and sporadic breast cancer risk: a meta-analysis. PLoS One 2012, 7(2):e31656.
• [19]Harkins LE, Matlaf LA, Soroceanu L, Klemm K, Britt WJ, Wang W, Bland KI, Cobbs CS: Detection of human cytomegalovirus in normal and neoplastic breast epithelium. Herpesviridae 2010, 1(1):8. BioMed Central Full Text
• [20]Cox B, Richardson A, Graham P, Gislefoss RE, Jellum E, Rollag H: Breast cancer, cytomegalovirus and Epstein-Barr virus: a nested case–control study. Br J Cancer 2010, 102(11):1665-1669.
• [21]Pandey JP, Kistner-Griffin E, Iwasaki M, Bu S, Deepe R, Black L, Kasuga Y, Hamada GS, Tsugane S: Genetic markers of immunoglobulin G and susceptibility to breast cancer. Hum Immunol 2012, 73(11):1155-1158.
• [22]Antonsson A, Bialasiewicz S, Rockett RJ, Jacob K, Bennett IC, Sloots TP: Exploring the prevalence of ten polyomaviruses and two herpes viruses in breast cancer. PLoS One 2012, 7(8):e39842.
• [23]Utrera-Barillas D, Valdez-Salazar HA, Gomez-Rangel D, Alvarado-Cabrero I, Aguilera P, Gomez-Delgado A, Ruiz-Tachiquin ME: Is human cytomegalovirus associated with breast cancer progression? Infectious agents and cancer 2013, 8(1):12. BioMed Central Full Text
• [24]Dziurzynski K, Chang SM, Heimberger AB, Kalejta RF, McGregor Dallas SR, Smit M, Soroceanu L, Cobbs CS: Consensus on the role of human cytomegalovirus in glioblastoma. Neuro-oncology 2012, 14(3):246-255.
• [25]Loenen WA, Bruggeman CA, Wiertz EJ: Immune evasion by human cytomegalovirus: lessons in immunology and cell biology. Seminars in immunology 2001, 13(1):41-49.
• [26]Hamidullah , Changkija B, Konwar R: Role of interleukin-10 in breast cancer. Breast cancer research and treatment 2012, 133(1):11-21.
• [27]Hachana M, Amara K, Ziadi S, Gacem RB, Korbi S, Trimeche M: Investigation of human JC and BK polyomaviruses in breast carcinomas. Breast cancer research and treatment 2012, 133(3):969-977.
• [28]Khan G, Philip PS, Naase M, Al Zarouni KM: No evidence for the involvement of XMRV or MCV in the pathogenesis of breast cancer. British journal of cancer 2012, 106(6):1166-1170.
• [29]Carbone M, Pass HI, Miele L, Bocchetta M: New developments about the association of SV40 with human mesothelioma. Oncogene 2003, 22(33):5173-5180.
• [30]Bergsagel DJ, Finegold MJ, Butel JS, Kupsky WJ, Garcea RL: DNA sequences similar to those of simian virus 40 in ependymomas and choroid plexus tumors of childhood. The New England journal of medicine 1992, 326(15):988-993.
• [31]Galateau-Salle F, Bidet P, Iwatsubo Y, Gennetay E, Renier A, Letourneux M, Pairon JC, Moritz S, Brochard P, Jaurand MC, et al.: SV40-like DNA sequences in pleural mesothelioma, bronchopulmonary carcinoma, and non-malignant pulmonary diseases. The Journal of pathology 1998, 184(3):252-257.
• [32]Martini F, Iaccheri L, Lazzarin L, Carinci P, Corallini A, Gerosa M, Iuzzolino P, Barbanti-Brodano G, Tognon M: SV40 early region and large T antigen in human brain tumors, peripheral blood cells, and sperm fluids from healthy individuals. Cancer research 1996, 56(20):4820-4825.
• [33]Wu M, Jung L, Cooper AB, Fleet C, Chen L, Breault L, Clark K, Cai Z, Vincent S, Bottega S, et al.: Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice. Proc Natl Acad Sci USA 2009, 106(17):7022-7027.
• [34]Hoenerhoff MJ, Shibata MA, Bode A, Green JE: Pathologic progression of mammary carcinomas in a C3(1)/SV40 T/t-antigen transgenic rat model of human triple-negative and Her2-positive breast cancer. Transgenic research 2011, 20(2):247-259.
• [35]Marcotte R, Muller WJ: Signal transduction in transgenic mouse models of human breast cancer–implications for human breast cancer. Journal of mammary gland biology and neoplasia 2008, 13(3):323-335.
• [36]Huschtscha LI, Neumann AA, Noble JR, Reddel RR: Effects of simian virus 40 T-antigens on normal human mammary epithelial cells reveal evidence for spontaneous alterations in addition to loss of p16(INK4a) expression. Experimental cell research 2001, 265(1):125-134.
• [37]Hachana M, Trimeche M, Ziadi S, Amara K, Korbi S: Evidence for a role of the Simian virus 40 in human breast carcinomas. Breast cancer research and treatment 2009, 113(1):43-58.
• [38]Orba Y, Suzuki T, Makino Y, Kubota K, Tanaka S, Kimura T, Sawa H: Large T antigen promotes JC virus replication in G2-arrested cells by inducing ATM- and ATR-mediated G2 checkpoint signaling. The Journal of biological chemistry 2010, 285(2):1544-1554.
• [39]Link A, Shin SK, Nagasaka T, Balaguer F, Koi M, Jung B, Boland CR, Goel A: JC virus mediates invasion and migration in colorectal metastasis. PloS one 2009, 4(12):e8146.
• [40]IARC Working Group on the Evaluation of Carcinogenic Risks to Humans: Human papillomaviruses. IARC monographs on the evaluation of carcinogenic risks to humans / World Health Organization, International Agency for Research on Cancer 2007, 90:1-636.
• [41]Wang T, Chang P, Wang L, Yao Q, Guo W, Chen J, Yan T, Cao C: The role of human papillomavirus infection in breast cancer. Med Oncol 2012, 29(1):48-55.
• [42]Simoes PW, Medeiros LR, Simoes Pires PD, Edelweiss MI, Rosa DD, Silva FR, Silva BR, Rosa MI: Prevalence of human papillomavirus in breast cancer: a systematic review. Int J Gynecol Cancer 2012, 22(3):343-347.
• [43]Joshi D, Buehring GC: Are viruses associated with human breast cancer? Scrutinizing the molecular evidence-response to James F. Holland and Beatriz GT Pogo. Breast Cancer Res Treat 2012, 136(1):303-307.
• [44]Hernandez J, Elahi A, Siegel E, Coppola D, Riggs B, Shibata D: HPV L1 capsid protein detection and progression of anal squamous neoplasia. American journal of clinical pathology 2011, 135(3):436-441.
• [45]Glenn WK, Heng B, Delprado W, Iacopetta B, Whitaker NJ, Lawson JS: Epstein-Barr virus, human papillomavirus and mouse mammary tumour virus as multiple viruses in breast cancer. PloS one 2012, 7(11):e48788.
• [46]Yasmeen A, Bismar TA, Kandouz M, Foulkes WD, Desprez PY, Al Moustafa AE: E6/E7 of HPV type 16 promotes cell invasion and metastasis of human breast cancer cells. Cell cycle (Georgetown, Tex) 2007, 6(16):2038-2042.
• [47]Akil N, Yasmeen A, Kassab A, Ghabreau L, Darnel AD, Al Moustafa AE: High-risk human papillomavirus infections in breast cancer in Syrian women and their association with Id-1 expression: a tissue microarray study. British journal of cancer 2008, 99(3):404-407.
• [48]Frega A, Lorenzon L, Bononi M, De Cesare A, Ciardi A, Lombardi D, Assorgi C, Gentile M, Moscarini M, Torrisi MR, et al.: Evaluation of E6 and E7 mRNA expression in HPV DNA positive breast cancer. European journal of gynaecological oncology 2012, 33(2):164-167.
• [49]Dimri G, Band H, Band V: Mammary epithelial cell transformation: insights from cell culture and mouse models. Breast cancer research : BCR 2005, 7(4):171-179. BioMed Central Full Text
• [50]Imyanitov EN, Hanson KP: Mechanisms of breast cancer. Drug Discovery Today: Disease Mechanisms 2004, 1(2):235-245.
• [51]Ferber MJ, Thorland EC, Brink AA, Rapp AK, Phillips LA, McGovern R, Gostout BS, Cheung TH, Chung TK, Fu WY, et al.: Preferential integration of human papillomavirus type 18 near the c-myc locus in cervical carcinoma. Oncogene 2003, 22(46):7233-7242.
• [52]McMurray HR, McCance DJ: Human papillomavirus type 16 E6 activates TERT gene transcription through induction of c-Myc and release of USF-mediated repression. Journal of virology 2003, 77(18):9852-9861.
• [53]Fan X, Liu Y, Chen JJ: Activation of c-Myc contributes to bovine papillomavirus type 1 E7-induced cell proliferation. The Journal of biological chemistry 2003, 278(44):43163-43168.
• [54]Gewin L, Galloway DA: E box-dependent activation of telomerase by human papillomavirus type 16 E6 does not require induction of c-myc. Journal of virology 2001, 75(15):7198-7201.
• [55]DeFilippis RA, Goodwin EC, Wu L, DiMaio D: Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence, and apoptosis in HeLa cervical carcinoma cells. J Virol 2003, 77(2):1551-1563.
• [56]Wang YW, Chang HS, Lin CH, Yu WC: HPV-18 E7 conjugates to c-Myc and mediates its transcriptional activity. The international journal of biochemistry & cell biology 2007, 39(2):402-412.
• [57]Aceto GM, Solano AR, Neuman MI, Veschi S, Morgano A, Malatesta S, Chacon RD, Pupareli C, Lombardi M, Battista P, et al.: High-risk human papilloma virus infection, tumor pathophenotypes, and BRCA1/2 and TP53 status in juvenile breast cancer. Breast cancer research and treatment 2010, 122(3):671-683.
• [58]de Villiers EM: Relationship between steroid hormone contraceptives and HPV, cervical intraepithelial neoplasia and cervical carcinoma. International journal of cancer Journal international du cancer 2003, 103(6):705-708.
• [59]Bittner JJ, Imagawa DT: The mammary tumor agent in extracts of frozen and unfrozen mammary cancers. Cancer research 1953, 13(7:1):525-528.
• [60]Pogo BGT, Holland JF: Possibilities of a viral etiology for human breast cancer - A review. Biol Trace Elem Res 1997, 56:131-142. ST - Possibilities of a viral etiology for human breast cancer - A review
• [61]Lawson JS, Glenn WK, Salmons B, Ye Y, Heng B, Moody P, Johal H, Rawlinson WD, Delprado W, Lutze-Mann L, et al.: Mouse mammary tumor virus-like sequences in human breast cancer. Cancer Res 2010, 70(9):3576-3585.
• [62]Callahan R, Mudunur U, Bargo S, Raafat A, McCurdy D, Boulanger C, Lowther W, Stephens R, Luke BT, Stewart C, et al.: Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors. Oncotarget 2012, 3(11):1320-1334.
• [63]Zenit-Zhuravleva EG, Lushnikova AA, Lyubchenko LN, Polevaya EB: 329 Expression of MMTV-homologous sequences in the patients with breast hyperplasia and ductal carcinoma in Situ. Eur J Cancer 2012, 48, Supplement 1(0):S139.
• [64]Wang Y, Melana SM, Baker B, Bleiweiss I, Fernandez-Cobo M, Mandeli JF, Holland JF, Pogo BGT: High prevalence of MMTV-like env gene sequences in gestational breast cancer. Med Oncol 2003, 20(3):233-236.
• [65]Labidi SI, Mrad K, Mezlini A, Ouarda MA, Combes JD, Ben Abdallah M, Ben Romdhane K, Viens P, Ben Ayed F: Inflammatory breast cancer in Tunisia in the era of multimodality therapy. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2008, 19:473-480.
• [66]Pogo BGT, Holland JF, Levine PH: Human mammary tumor virus in inflammatory breast cancer. Cancer 2010, 116:2741-2744. ST - Human Mammary Tumor Virus in Inflammatory Breast Cancer
• [67]Kim HH, Grande SM, Monroe JG, Ross SR: Mouse Mammary Tumor Virus Suppresses Apoptosis of Mammary Epithelial Cells through ITAM-Mediated Signaling. 2012.
• [68]Floor SL, Dumont JE, Maenhaut C, Raspe E: Hallmarks of cancer: of all cancer cells, all the time? Trends Mol Med 2012, 18(9):509-515.
• [69]Floor SL, Dumont JE, Maenhaut C, Raspe E: Hallmarks of cancer: of all cancer cells, all the time? Trends Mol Med 2012, 18(9):509-515.
• [70]Alibek K, Bekmurzayeva A, Mussabekova A, Sultankulov B: Using antimicrobial adjuvant therapy in cancer treatment: a review. Infectious Agents and Cancer 2012, 7(1):33. BioMed Central Full Text