The role of death-associated protein 3 in apoptosis, anoikis and human cancer

Cancer Cell International

Kefah Mokbel⁴  Abdul Kasem¹  Anup K Sharma⁴  Wen G Jiang²  Zubair S Khanzada²  Mona MAW Orakzai³  Umar Wazir⁴ 

[1] The London Breast Institute, Princess Grace Hospital, London, UK;Metastasis and Angiogenesis Research Group, University Department of Surgery, Cardiff University School of Medicine, Cardiff University, Cardiff, Wales, UK;Ayub Medical College, Abbottabad, Pakistan;Department of Breast Surgery, St. George’s Hospital and Medical School, University of London, London, UK

关键词: Breast cancer;    Oncogenesis;    Carcinogenesis;    Cancer;    Anoikis;    Death-associated protein 3;    Review;    Apoptosis;   

Others  :  1171054
DOI  :  10.1186/s12935-015-0187-z

 received in 2014-06-02, accepted in 2015-03-18,  发布年份 2015

【 摘 要 】

Death-associated protein 3 (DAP3) is a molecule with a significant role in the control of both apoptosis and anoikis. Apoptosis is the predominant type of programmed cell death (PCD) which may occur in response to irreparable damage to DNA, or in response to induction by inflammatory cells. Anoikis is subset of apoptosis which occurs in epithelial cells in response to detachment from the surrounding matrix. Both apoptosis and anoikis are of interest in the context of carcinogenesis. In this review, we shall discuss apoptosis and anoikis, and the recent literature regarding the role of DAP3 in both these pathways.

【 授权许可】

   
2015 Wazir et al.; licensee BioMed Central.

【 图 表 】

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