Rivaroxaban modulates electrical and mechanical characteristics of left atrium

Journal of Biomedical Science

Yi-Jen Chen¹  Shih-Ann Chen⁴  Jen-Hung Huang¹  Yung-Kuo Lin¹  Yao-Chang Chen²  Chien-Jung Chang³ 

[1] Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, 111 Hsin-Lung Road Sec. 3, Taipei 116, Taiwan;Department of Biomedical Engineering and Institute of Physiology, National Defense Medical Center, Taipei, Taiwan;Division of Cardiology, Tungs’ Taichung Metroharbor Hospital, Taichung, Taiwan;Division of Cardiology and Cardiovascular Research Center, Taipei Veterans General Hospital, Taipei, Taiwan

关键词: Cyclooxygenase;    Nitric oxide synthase;    Factor Xa;    Atrial fibrillation;    Rivaroxaban;   

Others  :  824184
DOI  :  10.1186/1423-0127-20-17

 received in 2012-12-26, accepted in 2013-03-11,  发布年份 2013

【 摘 要 】

Background

Rivaroxaban reduces stroke in patients with atrial fibrillation (AF). Left atrium (LA) plays a critical role in the pathophysiology of AF. However, the electromechanical effects of rivaroxaban on LA are not clear.

Results

Conventional microelectrodes and a whole-cell patch-clamp were used to record the action potentials (APs) and ionic currents in rabbit LA preparations and isolated single LA cardiomyocytes before and after the administration of rivaroxaban. Rivaroxaban (10, 30, 100, and 300 nM) concentration-dependently reduced LA (n = 7) AP durations at 90% repolarization (APD₉₀) from 76 ± 2 to 79 ± 3, 67 ± 4 (P < 0.05, vs. control), 59 ± 5, (P < 0.01, vs. control), and 56 ± 4 ms (P < 0.005, vs. control), respectively. Rivaroxaban (10, 30, 100, and 300 nM) concentration-dependently increased the LA (n = 7) diastolic tension by 351 ± 69 (P < 0.05, vs. control), 563 ± 136 (P < 0.05, vs. control), 582 ± 119 (P < 0.05, vs. control), and 603 ± 108 mg (P < 0.005, vs. control), respectively, but did not change LA contractility. In the presence of L-NAME (100 μM) and indomethacin (10 μM), additional rivaroxaban (300 nM) treatment did not significantly further increase the LA (n = 7) diastolic tension, but shortened the APD₉₀ from 73 ± 2 to 60 ± 6 ms (P < 0.05, vs. control). Rivaroxaban (100 nM) increased the L-type calcium current and ultra-rapid delayed rectifier potassium current, but did not change the transient outward potassium current in isolated LA cardiomyocytes.

Conclusions

Rivaroxaban modulates LA electrical and mechanical characteristics with direct ionic current effects.

【 授权许可】

   
2013 Chang et al.; licensee BioMed Central Ltd.

【 图 表 】

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