Relationship of resting heart rate and physical activity with insulin sensitivity in a population-based survey

Journal of Diabetes & Metabolic Disorders

Joseph Keawe‘aimoku Kaholokula²  David MKI Liu²  Andrew Grandinetti¹ 

[1] Department of Public Health Sciences, John A. Burns School of Medicine, University of Hawai‘i at Manoa, 1960 East–west Road D-104 L, Honolulu 96822, HI, USA;Department of Native Hawaiian Health, John A. Burns School of Medicine, University of Hawai‘i at Mānoa, Honolulu 96822, HI, USA

关键词: Epidemiology;    Cardiovascular;    Insulin resistance;    Oceanic ancestry group;    Asian Americans;   

Others  :  1211866
DOI  :  10.1186/s40200-015-0161-2

 received in 2014-12-22, accepted in 2015-04-11,  发布年份 2015

【 摘 要 】

Background

Resting heart rate (RHR) has been identified as an independent risk factor for cardiovascular disease and mortality, contributing to atherosclerosis, the progression of heart failure, and myocardial ischemia and infarction. This study examines the association RHR and physical activity has with insulin resistance and insulin secretion in a multiethnic cohort from North Kohala, Hawai‘i.

Methods

Cross-sectional data from 1,440 participants of Native Hawaiian, Japanese, Filipino, Caucasian, and mixed ethnic ancestries were analyzed for the study to include anthropometric measurements, and biochemical markers. Body fat was estimated by calculating body mass indices (BMI); body fat distribution by waist-hip ratios (WHR); and fasting plasma glucose and insulin levels were used to calculate insulin resistance using the Homeostasis Model (HOMA-IR). First phase insulin response was estimated using the insulin secretion ratio (ISR). Associations were estimated using general linear models (GLM).

Results

Caucasians had lower mean RHR than all other ethnic groups; there were no statistically significant differences between other ethnic groups on mean RHR. HOMA-IR was associated with ethnic group, BMI and WHR, PA and RHR, while ISR was associated with age, ethnic group and BMI, but none of the primary risk factors. Both RHR and physical activity level remained significant for insulin resistance.

Conclusions

In a multiethnic cohort from a rural community in Hawai‘i, increased RHR and a lower level of physical activity were both independently associated with increased risk for the development of insulin resistance, suggesting cardiovascular fitness may be as important as physical activity in preventing insulin resistance.

【 授权许可】

   
2015 Grandinetti et al.; licensee BioMed Central.

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