Permissive underfeeding versus target enteral feeding in adult critically ill patients (PermiT Trial): a study protocol of a multicenter randomized controlled trial

Trials

Bushra Sami⁴  Lara Afesh⁴  Musharaf Sadat⁴  Othman Solaiman³  Sangeeta Mehta⁶  Lauralyn McIntyre¹  Gwynne Jones¹  Maram Sakkijha²  Hani M Tamim⁵  Hasan M Al-Dorzi²  Abdulaziz S Aldawood²  Samir H Haddad²  Yaseen M Arabi⁷ 

[1] Ottawa Hospital Research Institute, Ottawa, Canada;King Abdulaziz Medical City, Riyadh, Saudi Arabia;King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia;King Abdullah International Medical Research Center, Riyadh, Saudi Arabia;King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia;Mount Sinai Hospital, Toronto, Canada;Chairman Intensive Care Department, Medical Director Respiratory Services, Associate Professor, College of Medicine, King Abdul Aziz Medical City, King Saud bin Abdulaziz University for Health Sciences, 1425, PO Box 22490, Riyadh, 11426, Kingdom of Saudi Arabia

关键词: Mortality;    Insulin;    Infections;    Caloric restriction;    Intensive Care Units;    Enteral nutrition;   

Others  :  1095267
DOI  :  10.1186/1745-6215-13-191

 received in 2012-07-18, accepted in 2012-09-24,  发布年份 2012

【 摘 要 】

Background

Nutritional support is an essential part of the management of critically ill patients. However, optimal caloric intake has not been systematically evaluated. We aim to compare two strategies of enteral feeding: permissive underfeeding versus target feeding.

Method/Design

This is an international multi-center randomized controlled trial in critically ill medical- surgical adult patients. Using a centralized allocation, 862 patients will be randomized to permissive underfeeding or target feeding. Patients in the permissive group receive 50% (acceptable range is 40% to 60%) of the calculated caloric requirement, while those in the targeted group receive 100% (acceptable range 70% to 100%) of the calculated caloric requirement. The primary outcome is 90-day all-cause mortality. Secondary outcomes include ICU and hospital mortality, 28-day, and 180-day mortality as well as health care-associated infections, organ failure, and length of stay in the ICU and hospital. The trial has 80% power to detect an 8% absolute reduction in 90-day mortality assuming a baseline risk of death of 25% at an alpha level of 0.05.

Discussion

Patient recruitment started in November 2009 and is currently active in five centers. The Data Monitoring Committee advised continuation of the trial after the first interim analysis. The study is expected to finish by November 2013.

Trial registration

Current Controlled Trials ISRCTN68144998

【 授权许可】

   
2012 Arabi et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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