A review on SNP and other types of molecular markers and their use in animal genetics

Genetics Selection Evolution

André Eggen²  Magali SanCristobal¹  Denis Milan¹  Alain Vignal¹ 

[1] Laboratoire de génétique cellulaire, Inra, chemin de Borde-Rouge, Auzeville BP 27, 31326 Castanet-Tolosan cedex, France;Laboratoire de génétique biochimique et de cytogénétique, Inra, domaine de Vilvert, 78352 Jouy-en-Josas cedex, France

关键词: polymorphism;    genome;    molecular marker;    microsatellite;    SNP;   

Others  :  1094565
DOI  :  10.1186/1297-9686-34-3-275

 received in 2002-02-11, accepted in 2002-03-08,  发布年份 2002

【 摘 要 】

During the last ten years, the use of molecular markers, revealing polymorphism at the DNA level, has been playing an increasing part in animal genetics studies. Amongst others, the microsatellite DNA marker has been the most widely used, due to its easy use by simple PCR, followed by a denaturing gel electrophoresis for allele size determination, and to the high degree of information provided by its large number of alleles per locus. Despite this, a new marker type, named SNP, for Single Nucleotide Polymorphism, is now on the scene and has gained high popularity, even though it is only a bi-allelic type of marker. In this review, we will discuss the reasons for this apparent step backwards, and the pertinence of the use of SNPs in animal genetics, in comparison with other marker types.

【 授权许可】

   
2002 INRA, EDP Sciences