Investigations of renal function using the level of neutrophil gelatinase-associated lipocalin associated with single-dose of cisplatin during chemotherapy

Diagnostic Pathology

Aram Mokarizadeh³  Emad Yahaghi⁶  Mojtaba Zarea⁴  Mostafa Fallah Joshaghani²  Mojtaba Dolatabadi⁵  Seyed Hesamoddin Mirjalili⁵  Omid Maghsoudi¹ 

[1] Doctor of Veterinary Medicine (DVM), Faculty of Veterinary Medicine, Islamic Azad University, Karaj Branch, Karaj, Iran;Under graduate of Veterinary Medicine, Faculty of Veterinary Medicine, Islamic Azad University, Karaj Branch, Karaj, Iran;Cellular & Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran;Center for Chemical Biology, Indian Institute of Chemical Technology (iict), Tarnaka, Hyderabad, India;Doctor of Veterinary Medicine (DVM), Karaj, Iran;Baqiyatallah University of Medical Sciences, Tehran, Iran

关键词: Marker;    Cisplatin;    Tumor;    Kidney;    Pathology;   

Others  :  1219333
DOI  :  10.1186/s13000-015-0338-5

 received in 2015-06-01, accepted in 2015-06-27,  发布年份 2015

【 摘 要 】

Background

Neutrophil gelatinase-associated lipocalin (NGAL) is known as a primary indicator of acute and chronic renal and can be effective in chronic kidney injury (CKI) with kidney tumors cisplatin (CP) chemotherapy. The aim of this study was to evaluate serum and urinary biomarker including NGAL (sNGAL and uNGAL) in canine with solid renal tumors who suffered from cisplatin after short and long-term chemotherapy.

Methods

In this study, in treatment and control groups, canine (n = 10 and n = 5) were administered cisplatin at 1.2 mg/kg/day (i.v.) for five consecutive days with CKI and without CKI, respectively. Serum and urine NGAL levels (ng/mL) were evaluated at 0, 1, 5, 9, 13, 17, 21, 25 and 29 days after drug injection versus baseline in treated and control groups.

Results

Canine in treatment group had shown symptoms of toxicity of cisplatin. The results indicated the higher concentrations of serum, sNGAL and uNGAL (P = 0.024; P = 0.011) compared with control group (P = 0.701, P = 0.612), (Table 2, Figs. 1 and 2). Indeed, our results showed that canine with CKI were associated with higher levels of sNGAL and uNGAL compared with control group without CKI. Moreover, the highest level of uNGAL was seen in comparison with sNGAL, after a high dose (1.2 mg/kg) administration of CP.

Conclusion

Our data suggested that U-NGAL may be useful for monitoring of renal injury in CKI patients that exposed with cisplatin. Furthermore, a primary elevate in urinary NGAL expulsion may help in identifying cases at danger of cisplatin-induced CKI that might profit from innovative remedies to prevent cisplatin nephrotoxicity.

【 授权许可】

   
2015 Maghsoudi et al.

【 图 表 】

Fig. 1.

Fig. 2.

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