Adenosine triphosphatases of thermophilic archaeal double-stranded DNA viruses

Cell & Bioscience

Sarah J Butcher³  Roger A Garrett¹  Susanne Erdmann¹  Lotta J Happonen² 

[1] Archaea Centre, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen N, Denmark;Department of Clinical Sciences, Division of Infection Medicine, Lund University, SE-221 84 Lund, Sweden;Institute of Biotechnology, University of Helsinki, (Viikinkaari 1), P.O. Box 65, FI-00014 Helsinki, Finland

关键词: MoxR ATPase;    Genome injection;    Genome packaging;    Virus;    Archaeal;    ATPase;   

Others  :  1149540
DOI  :  10.1186/2045-3701-4-37

 received in 2013-09-04, accepted in 2014-06-13,  发布年份 2014

【 摘 要 】

Adenosine triphosphatases (ATPases) of double-stranded (ds) DNA archaeal viruses are structurally related to the AAA+ hexameric helicases and translocases. These ATPases have been implicated in viral life cycle functions such as DNA entry into the host, and viral genome packaging into preformed procapsids. We summarize bioinformatical analyses of a wide range of archaeal ATPases, and review the biochemical and structural properties of those archaeal ATPases that have measurable ATPase activity. We discuss their potential roles in genome delivery into the host, virus assembly and genome packaging in comparison to hexameric helicases and packaging motors from bacteriophages.

【 授权许可】

   
2014 Happonen et al.; licensee BioMed Central Ltd.

【 图 表 】

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