The effect of nebulized salbutamol or isotonic saline on exercise-induced bronchoconstriction in elite skaters following a 1,500-meter race: study protocol for a randomized controlled trial

Trials

Frans HC de Jongh⁵  Nick HT ten Hacken⁴  Jaap Westbroek²  Margryt Gerritsma³  Jean MM Driessen¹ 

[1] Sports Medicine, Tjongerschans Hospital, Heerenveen, the Netherlands;Pulmonology, Tjongerschans Hospital, Heerenveen, the Netherlands;Sport and Management, Hanzehogeschool, Groningen, the Netherlands;Pulmonology, University Medical Centre Groningen, Groningen, the Netherlands;Pediatric Pulmonology, Academic Medical Centre, Amsterdam, the Netherlands

关键词: Small airways;    Forced oscillation technique;    Salbutamol;    Exercise-induced bronchoconstriction;    Elite athletes;   

Others  :  1093497
DOI  :  10.1186/1745-6215-14-204

 received in 2012-12-21, accepted in 2013-06-05,  发布年份 2013

【 摘 要 】

Background

Prevalence of exercise-induced bronchoconstriction (EIB) is high in elite athletes, especially after many years training in cold and dry air conditions. The primary treatment of EIB is inhaling a short-acting beta-2-agonist such as salbutamol. However, professional speed skaters also inhale nebulized isotonic saline or tap water before and after a race or intense training. The use of nebulized isotonic saline or tap water to prevent EIB has not been studied before, raising questions about safety and efficacy. The aim of this study is to analyze the acute effect of nebulized isotonic saline or salbutamol on EIB in elite speed skaters following a1,500-meter race.

Methods

This randomized controlled trial compares single dose treatment of 1 mg nebulized salbutamol in 4 mL of isotonic saline, or with 5 mL of isotonic saline. A minimum of 13 participants will be allocated in each treatment group. Participants should be between 18 and 35 years of age and able to skate 1,500 m in less than 2 min 10 s (women) or 2 min 05 s (men). Repeated measurements of spirometry, forced oscillation technique, and electromyography will be performed before and after an official 1,500-m race. Primary outcome of the study is the difference in fall in FEV₁ after exercise in the different treatment groups. The trial is currently enrolling participants.

Discussion

Elite athletes run the risk of pulmonary inflammation and remodeling as a consequence of their frequent exercise, and thus increased ventilation in cold and dry environments. Although inhalation of nebulized isotonic saline is commonplace, no study has ever investigated the safety or efficacy of this treatment.

Trial registration

This trial protocol was registered with the Dutch trial registration for clinical trials under number NTR3550

【 授权许可】

   
2013 Driessen et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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