A major shift of viral and nutritional risk factors affects the hepatocellular carcinoma risk among Ivorian patients: a preliminary report

Infectious Agents and Cancer

Pascal Pineau²  Innocent Adoubi¹  Djeneba Ngnoh Ouattara³  Stéphane Romaric Denoman⁴  Moussa Doumbia⁴  Alphonsine Kouassi M’Bengue⁴ 

[1] Cancer registry-Teaching Hospital of Treichville, Department of Immunology and Cancerology, Medical Teaching Félix Houphouet-Boigny University, Abidjan 01, BPV 166, Ivory Coast;Unité “Organisation nucléaire et oncogenèse”, INSERM U993, Institut Pasteur, Paris, France;Department of Epidemiology and Clinical survey, Pasteur Institute, Abidjan 01 BP 490 01, Ivory Coast;Unit of bacterial and viral serology, Pasteur Institute Ivory Coast - Department of Microbiology, Medical Teaching Félix Houphouet-Boigny University, Abidjan 01 BPV 166, Ivory Coast

关键词: Maize;    Hepatitis C virus;    Hepatitis B virus;    Hepatocellular carcinoma;    Ethnicity;    Aflatoxin B1;   

Others  :  1216859
DOI  :  10.1186/s13027-015-0013-1

 received in 2014-12-12, accepted in 2015-06-04,  发布年份 2015

【 摘 要 】

Hepatocellular carcinoma (HCC) is a major public health concern in Sub-Saharan Africa. Early research in Ivory Coast showed that chronic hepatitis B and aflatoxin B1 exposure were the two most important etiological agents of HCC in the country but, surprisingly, no survey analyzing HCC etiologies has been conducted since decades.

In a preliminary report, we characterized for hepatitis B and C markers 30 consecutive cases of HCC recruited from Abidjan hospitals between June 2011 and December 2012. Nutritional and lifestyle features of patients were analyzed as well. The mean age of the patients was 53 ± 15 years with a sex ratio (M:F = 2.7). HBsAg was the most frequent viral marker in the series (63 %). All HBV isolates belonged to genotype E. With regards to regional standard, anti-HCV reached a very high level (47 %) in the present series. Hepatitis C was more frequent among patients living outside Abidjan (83 vs 23 %, P = 0.009). Patients living in Abidjan were significantly younger than individual living elsewhere in the country (48 ± 14 vs 60 ± 16 years old, P = 0.038) reflecting a possible role for local environmental pollution in tumor progression. Finally, we observed that patients born in Mandé/Gur-speaking regions (North) were younger (48 ± 14 vs 59 ± 15, P = 0.05) and consumed maize more frequently (80 vs 26 %, P = 0.009) than other patients. Interestingly, maize consumption was associated with a trend for aminotransferases elevation (mean = 1.7-1.8 fold, P = 0.06) suggesting a direct hepatic toxicity of this staple food in Ivory Coast. In conclusion, our work indicates that HCC epidemiology underwent recently major drifts in Ivory Coast.

【 授权许可】

   
2015 M'Bengue et al.

【 图 表 】

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