A note on QTL detecting for censored traits

Genetics Selection Evolution

Yixin Fang¹ 

[1] Department of Statistics, Columbia University, New York, NY 10027, USA

关键词: interval mapping;    censored trait;    QTL detecting;   

Others  :  1094144
DOI  :  10.1186/1297-9686-38-2-221

 received in 2005-08-09, accepted in 2005-10-06,  发布年份 2006

【 摘 要 】

Most existing statistical methods for mapping quantitative trait loci (QTL) assume that the phenotype follows a normal distribution and that it is fully observed. However, some phenotypes have skewed distributions and may be censored. This note proposes a simple and efficient approach to QTL detecting for censored traits with the Cox PH model without estimating the baseline hazard function which is "nuisance".

【 授权许可】

   
2006 INRA, EDP Sciences