High plasma uric acid concentration: causes and consequences

Diabetology & Metabolic Syndrome

Roberto Carlos Burini¹  Erick Prado de Oliveira² 

[1] Center for exercise metabolism and nutrition (CeMENutri), Department of Public Health, Botucatu School of Medicine (UNESP), Botucatu, Brazil;CeMENutri-Faculdade de Medicina, Departamento de Saúde Pública (FMBUNESP), Distrito de Rubião Jr, s/n, 18.618-970 Botucatu, SP, Brazil

关键词: Metabolic syndrome;    Risk;    Protection;    Diet;    Uric acid;   

Others  :  817385
DOI  :  10.1186/1758-5996-4-12

 received in 2012-01-17, accepted in 2012-04-04,  发布年份 2012

【 摘 要 】

High plasma uric acid (UA) is a precipitating factor for gout and renal calculi as well as a strong risk factor for Metabolic Syndrome and cardiovascular disease. The main causes for higher plasma UA are either lower excretion, higher synthesis or both. Higher waist circumference and the BMI are associated with higher insulin resistance and leptin production, and both reduce uric acid excretion. The synthesis of fatty acids (tryglicerides) in the liver is associated with the de novo synthesis of purine, accelerating UA production. The role played by diet on hyperuricemia has not yet been fully clarified, but high intake of fructose-rich industrialized food and high alcohol intake (particularly beer) seem to influence uricemia. It is not known whether UA would be a causal factor or an antioxidant protective response. Most authors do not consider the UA as a risk factor, but presenting antioxidant function. UA contributes to > 50% of the antioxidant capacity of the blood. There is still no consensus if UA is a protective or a risk factor, however, it seems that acute elevation is a protective factor, whereas chronic elevation a risk for disease.

【 授权许可】

   
2012 de Oliveira and Burini; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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