Cardiac inflammatory myofibroblastic tumor: does it recur after complete surgical resection in an adult?

Journal of Cardiothoracic Surgery

Yu Wang¹  Mei Liu²  Cangsong Xiao³  Xuedong Yang¹ 

[1]Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People’s Republic of China

[2]Department of Pathology, Chinese PLA General Hospital, Beijing, People’s Republic of China

[3]Department of Cardiac Surgery, Chinese PLA General Hospital, Beijing, People’s Republic of China

关键词: Prognosis;    Surgery;    Heart;    Inflammatory myofibroblastic tumor;   

Others  :  1153265
DOI  :  10.1186/1749-8090-7-44

 received in 2012-01-06, accepted in 2012-04-17,  发布年份 2012

【 摘 要 】

Inflammatory myofibroblastic tumor is currently considered to be a low-grade neoplasm, and it rarely involves the heart. We reported a rare case of a 59-year-old female who received cardiac surgery for complete resection of inflammatory myofibroblastic tumor in the left atrium. Five months after surgery, the patient presented with acute cardiogenic pulmonary edema and subsequent sudden death due to a left atrial tumor which protruded into the left ventricle through mitral annulus during diastole. The recurrence of inflammatory myofibroblastic tumor in the left atrium was strongly suggested clinically.

【 授权许可】

   
2012 Yang et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1 .

Figure 2 .

【 参考文献 】

• [1]Pucci A, Valori A, Muscio M, Garofalo L, Ferroni F, Abbruzzese PA: Asymptomatic inflammatory myofibroblastic tumor of the heart: immunohistochemical profile, differential diagnosis, and review of the literature. Cardiovasc Pathol 2009, 18:187-190.
• [2]Gonzalez-Crussi F, Vanderbilt BL, Miller JK: Unusual intracardiac tumor in a child. Inflammatory pseudotumor or "granulomatous" variant of myxoma? Cancer 1975, 36:2214-2226.
• [3]Li L, Burke A, He J, Chang L, Zielke HR, Fowler DR: Sudden unexpected death due to inflammatory myofibroblastic tumor of the heart: a case report and review of the literature. Int J Legal Med 2011, 125:81-85.
• [4]Burke A, Li L, Kling E, Kutys R, Virmani R, Miettinen M: Cardiac inflammatory myofibroblastic tumor: a "benign" neoplasm that may result in syncope, myocardial infarction, and sudden death. Am J Surg Pathol 2007, 31:1115-1122.
• [5]Coffin CM, Humphrey PA, Dehner LP: Extrapulmonary inflammatory myofibroblastic tumor: a clinical and pathological survey. Semin Diagn Pathol 1998, 15:85-101.
• [6]Coffin CM, Watterson J, Priest JR, Dehner LP: Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 1995, 19:859-872.
• [7]Coffin CM, Dehner LP, Meis-Kindblom JM: Inflammatory myofibroblastic tumor, inflammatory fibrosarcoma, and related lesions: an historical review with differential diagnostic considerations. Semin Diagn Pathol 1998, 15:102-110.
• [8]Meis JM, Enzinger FM: Inflammatory fibrosarcoma of the mesentery and retroperitoneum. A tumor closely simulating inflammatory pseudotumor. Am J Surg Pathol 1991, 15:1146-1156.
• [9]Gleason BC, Hornick JL: Inflammatory myofibroblastic tumours: where are we now? J Clin Pathol 2008, 61:428-437.
• [10]Hartyanszky IL, Kadar K, Hubay M: Rapid recurrence of an inflammatory myofibroblastic tumor in the right ventricular outflow tract. Cardiol Young 2000, 10:271-274.